Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity

Seyed R. Tabaei, Jurriaan J J Gillissen, Min Chul Kim, James C S Ho, Bo Liedberg, Atul N. Parikh, Nam Joon Cho

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Using single-particle tracking, we investigate the interaction of small unilamellar vesicles (SUVs) that are electrostatically tethered to the freestanding membrane of a giant unilamellar vesicle (GUV). We find that the surface mobility of the GUV-riding SUVs is Brownian, insensitive to the bulk viscosity, vesicle size, and vesicle fluidity but strongly altered by the viscosity of the underlying membrane. Analyzing the diffusional behavior of SUVs within the Saffman-Delbrück model for the dynamics of membrane inclusions supports the notion that the mobility of the small vesicles is coupled to that of dynamically induced lipid clusters within the target GUV membrane. The reversible binding also offers a nonperturbative means for measuring the viscosity of biomembranes, which is an important parameter in cell physiology and function.

Original languageEnglish (US)
Pages (from-to)5445-5450
Number of pages6
JournalLangmuir
Volume32
Issue number21
DOIs
StatePublished - May 31 2016

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

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    Tabaei, S. R., Gillissen, J. J. J., Kim, M. C., Ho, J. C. S., Liedberg, B., Parikh, A. N., & Cho, N. J. (2016). Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity. Langmuir, 32(21), 5445-5450. https://doi.org/10.1021/acs.langmuir.6b00985