Bronchomalacia in Dogs with Myxomatous Mitral Valve Degeneration

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Cough in the geriatric small breed dog with myxomatous mitral valve degeneration (MMVD), a large left atrium, and absence of heart failure often is attributed to compression of the left mainstem bronchus by the left atrium. Studies investigating this syndrome are lacking in dogs. Hypothesis: Airway collapse is independent of left atrial enlargement. Animals: A total of 16 dogs presenting with chronic cough in the absence of congestive heart failure. Group 1 dogs (n = 10) had moderate-to-severe left atrial enlargement based on an echocardiographically calculated left atrial:aortic surface area [LA:Ao(a)] > 6. Group 2 dogs (n = 6) had no to mild left atrial enlargement [LA:Ao(a) ≤ 6]. Methods: Dogs were prospectively evaluated. CBC, biochemistry, urinalysis, cervical and thoracic radiographs, fluoroscopy, echocardiography, and bronchoscopy were performed. Bronchoscopic abnormalities were compared between groups using Fisher's Exact Test. P < .05 was considered significant. Results: Fluoroscopy identified airway collapse in both groups. Bronchoscopic evidence of airway collapse >50% was observed in multiple bronchi with no difference between groups. All dogs had inflammation on airway cytology with respiratory infection in 1 dog in group 2. Left atrial size was interpreted radiographically as enlarged in 9 of 10 group 1 dog and in 2 of 6 group 2 dogs. VHS was above normal in both groups of dogs regardless of echocardiographic evidence of cardiomegaly. Conclusions: Results failed to identify an association between left atrial enlargement and airway collapse in dogs with MMVD, but did suggest that airway inflammation is common in dogs with airway collapse.

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume26
Issue number2
DOIs
StatePublished - Mar 2012

Fingerprint

Bronchomalacia
Mitral Valve
Dogs
dogs
bronchi
cough
heart failure
Bronchi
Heart Atria
Cough
surface area
inflammation
Heart Failure
bronchoscopy
Inflammation
urinalysis
echocardiography
Urinalysis
chest
Fluoroscopy

Keywords

  • Airway collapse
  • Chronic bronchitis
  • Left atrial enlargement

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Bronchomalacia in Dogs with Myxomatous Mitral Valve Degeneration. / Singh, M. K.; Johnson, Lynelle R; Kittleson, Mark D; Pollard, Rachel E.

In: Journal of Veterinary Internal Medicine, Vol. 26, No. 2, 03.2012, p. 312-319.

Research output: Contribution to journalArticle

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abstract = "Background: Cough in the geriatric small breed dog with myxomatous mitral valve degeneration (MMVD), a large left atrium, and absence of heart failure often is attributed to compression of the left mainstem bronchus by the left atrium. Studies investigating this syndrome are lacking in dogs. Hypothesis: Airway collapse is independent of left atrial enlargement. Animals: A total of 16 dogs presenting with chronic cough in the absence of congestive heart failure. Group 1 dogs (n = 10) had moderate-to-severe left atrial enlargement based on an echocardiographically calculated left atrial:aortic surface area [LA:Ao(a)] > 6. Group 2 dogs (n = 6) had no to mild left atrial enlargement [LA:Ao(a) ≤ 6]. Methods: Dogs were prospectively evaluated. CBC, biochemistry, urinalysis, cervical and thoracic radiographs, fluoroscopy, echocardiography, and bronchoscopy were performed. Bronchoscopic abnormalities were compared between groups using Fisher's Exact Test. P < .05 was considered significant. Results: Fluoroscopy identified airway collapse in both groups. Bronchoscopic evidence of airway collapse >50{\%} was observed in multiple bronchi with no difference between groups. All dogs had inflammation on airway cytology with respiratory infection in 1 dog in group 2. Left atrial size was interpreted radiographically as enlarged in 9 of 10 group 1 dog and in 2 of 6 group 2 dogs. VHS was above normal in both groups of dogs regardless of echocardiographic evidence of cardiomegaly. Conclusions: Results failed to identify an association between left atrial enlargement and airway collapse in dogs with MMVD, but did suggest that airway inflammation is common in dogs with airway collapse.",
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