Bronchogenic carcinoma: Analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling

Theresa C. McLoud, Pierre M. Bourgouin, Rona W. Greenberg, John P. Kosiuk, Philip A. Templeton, Jo Anne O Shepard, Elizabeth H Moore, John C. Wain, Douglas J. Mathisen, Hermes C. Grillo

Research output: Contribution to journalArticle

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Abstract

One hundred forty-three patients with bronchogenic carcinoma were studied prospectively with computed tomography (CT) to determine the accuracy of CT in the evaluation of mediastinal nodal metastases. Mediastinal lymph nodes were localized according to the lymph node mapping scheme of the American Thoracic Society and were considered abnormal if they exceeded 1 cm in short-axis diameter. All patients underwent surgical staging, which consisted of either mediastinoscopy alone or mediastinoscopy and thoracotomy. At the time of surgical staging, all accessible nodes were either removed or sampled. The sensitivity of CT for mediastinal nodes on a perpatient basis was 64%, with a specificity of 62%. The sensitivity of CT for individual nodal stations involved with tumor was only 44%. The presence of obstructive pneumonitis did not appreciably alter the sensitivity of CT, but the specificity was lower (43%). The likelihood of metastases increased with lymph node size; however, seven of 19 (37%) lymph nodes that measured 2-4 cm in short-axis diameter were hyperplastic and did not contain metastases. The relative insensitivity of CT makes formal nodal sampling at the time of mediastinoscopy or thoracotomy essential to detect lymph node metastases.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalRadiology
Volume182
Issue number2
StatePublished - Feb 1992

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Bronchogenic Carcinoma
Mediastinum
Lymph Nodes
Tomography
Mediastinoscopy
Neoplasm Metastasis
Thoracotomy
Pneumonia
Neoplasms

Keywords

  • Lymphatic system, neoplasms, 67.337
  • Mediastinum, CT, 67.1211
  • Mediastinum, neoplasms, 67.3235

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

McLoud, T. C., Bourgouin, P. M., Greenberg, R. W., Kosiuk, J. P., Templeton, P. A., Shepard, J. A. O., ... Grillo, H. C. (1992). Bronchogenic carcinoma: Analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. Radiology, 182(2), 319-323.

Bronchogenic carcinoma : Analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. / McLoud, Theresa C.; Bourgouin, Pierre M.; Greenberg, Rona W.; Kosiuk, John P.; Templeton, Philip A.; Shepard, Jo Anne O; Moore, Elizabeth H; Wain, John C.; Mathisen, Douglas J.; Grillo, Hermes C.

In: Radiology, Vol. 182, No. 2, 02.1992, p. 319-323.

Research output: Contribution to journalArticle

McLoud, TC, Bourgouin, PM, Greenberg, RW, Kosiuk, JP, Templeton, PA, Shepard, JAO, Moore, EH, Wain, JC, Mathisen, DJ & Grillo, HC 1992, 'Bronchogenic carcinoma: Analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling', Radiology, vol. 182, no. 2, pp. 319-323.
McLoud TC, Bourgouin PM, Greenberg RW, Kosiuk JP, Templeton PA, Shepard JAO et al. Bronchogenic carcinoma: Analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. Radiology. 1992 Feb;182(2):319-323.
McLoud, Theresa C. ; Bourgouin, Pierre M. ; Greenberg, Rona W. ; Kosiuk, John P. ; Templeton, Philip A. ; Shepard, Jo Anne O ; Moore, Elizabeth H ; Wain, John C. ; Mathisen, Douglas J. ; Grillo, Hermes C. / Bronchogenic carcinoma : Analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. In: Radiology. 1992 ; Vol. 182, No. 2. pp. 319-323.
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