Abstract
Two bronchoalveolar lavages, 24 h apart, were performed on 15 foals, ranging in age from 1 to 21 days. In the first lavage, a numerical deficiency in alveolar macrophages was demonstrated in foals up to 2 weeks of age when compared with older (2-3 years of age) horses. Alveolar macrophages obtained from the lungs of 2-3-day-old foals also demonstrated significant impaired chemotactic function. In the second lavage, although an increase of alveolar macrophages was noted, a dramatic increase of polymorphonuclear neutrophil (PMN) mobilization occurred in the foals, thus providing a phagocytic back-up for the alveolar macrophage host defence mechanism. In contrast, PMN response to lower respiratory tract perturbation in older horses was negligible. The results of this study suggest that the numerical and chemotactic deficiency found in alveolar macrophages of the neonate may play a role in the foal's susceptibility to respiratory disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 587-592 |
| Number of pages | 6 |
| Journal | Journal of reproduction and fertility. Supplement |
| Volume | 35 |
| State | Published - Dec 1 1987 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Bronchoalveolar lavage in the newborn foal. / Liu, Irwin; Walsh, E. M.; Bernoco, M.; Cheung, A. T.
In: Journal of reproduction and fertility. Supplement, Vol. 35, 01.12.1987, p. 587-592.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bronchoalveolar lavage in the newborn foal.
AU - Liu, Irwin
AU - Walsh, E. M.
AU - Bernoco, M.
AU - Cheung, A. T.
PY - 1987/12/1
Y1 - 1987/12/1
N2 - Two bronchoalveolar lavages, 24 h apart, were performed on 15 foals, ranging in age from 1 to 21 days. In the first lavage, a numerical deficiency in alveolar macrophages was demonstrated in foals up to 2 weeks of age when compared with older (2-3 years of age) horses. Alveolar macrophages obtained from the lungs of 2-3-day-old foals also demonstrated significant impaired chemotactic function. In the second lavage, although an increase of alveolar macrophages was noted, a dramatic increase of polymorphonuclear neutrophil (PMN) mobilization occurred in the foals, thus providing a phagocytic back-up for the alveolar macrophage host defence mechanism. In contrast, PMN response to lower respiratory tract perturbation in older horses was negligible. The results of this study suggest that the numerical and chemotactic deficiency found in alveolar macrophages of the neonate may play a role in the foal's susceptibility to respiratory disease.
AB - Two bronchoalveolar lavages, 24 h apart, were performed on 15 foals, ranging in age from 1 to 21 days. In the first lavage, a numerical deficiency in alveolar macrophages was demonstrated in foals up to 2 weeks of age when compared with older (2-3 years of age) horses. Alveolar macrophages obtained from the lungs of 2-3-day-old foals also demonstrated significant impaired chemotactic function. In the second lavage, although an increase of alveolar macrophages was noted, a dramatic increase of polymorphonuclear neutrophil (PMN) mobilization occurred in the foals, thus providing a phagocytic back-up for the alveolar macrophage host defence mechanism. In contrast, PMN response to lower respiratory tract perturbation in older horses was negligible. The results of this study suggest that the numerical and chemotactic deficiency found in alveolar macrophages of the neonate may play a role in the foal's susceptibility to respiratory disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023475797&partnerID=8YFLogxK
M3 - Article
C2 - 3479611
AN - SCOPUS:0023475797
VL - 35
SP - 587
EP - 592
JO - Journal of reproduction and fertility. Supplement
JF - Journal of reproduction and fertility. Supplement
SN - 0449-3087
ER -