Bronchiolitis obliterans syndrome in lung transplant recipients: Use of spirometrically gated CT

Friedrich D Knollmann, Ralf Ewert, Tarja Wundrich, Roland Hetzer, Roland Felix

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Purpose: To assess the potential use of spirometrically gated lung computed tomographic (CT) findings in the diagnosis of bronchiolitis obliterans syndrome after lung transplantation. Materials and methods: Forty-nine lung transplant recipients were examined at least 8 months after surgery with spirometrically gated thin-section CT of the lung. In addition to visual signs of small-airway disease at CT, mean lung attenuation and the SD were numerically determined and compared with the results of lung function testing at the time of the CT examination and 1 year later by using factorial analysis of variance. Results: Mean lung attenuation was significantly lower in patients who developed bronchiolitis obliterans syndrome within 1 year after the CT study (-837 HU ± 3) than in patients with persistent normal lung function (-812 HU ± 3, P < .001). With an optimal threshold, sensitivity was 69%, specificity was 71%, and accuracy was 84%. Visual analysis did not significantly contribute to the prognostic power of CT. Conclusion: Spirometrically gated CT measurements of lung attenuation can be used to predict the onset of bronchiolitis obliterans syndrome after lung transplantation.

Original languageEnglish (US)
Pages (from-to)655-662
Number of pages8
JournalRadiology
Volume225
Issue number3
StatePublished - Dec 2002
Externally publishedYes

Keywords

  • Bronchiolitis obliterans
  • Computed tomography (CT), quantitative
  • Computed tomography (CT), thinsection
  • Lung, transplantation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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