Bromethalin poisoning in a raccoon (Procyon lotor)

Diagnostic considerations and relevance to nontarget wildlife

Adrienne C. Bautista, Leslie Woods, Mike S. Filigenzi, Birgit Puschner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Submission of a raccoon (Procyon lotor) for necropsy following exhaustion at a California wildlife care center revealed minimal gross pathologic changes and only mild vacuolar changes in the white matter of the brain. Turquoise granular material was noted in the gastrointestinal tract and was submitted for toxicological testing along with portions of the brain, liver, kidney, and mesenteric and perirenal adipose tissues. Testing of the turquoise material for 7 anticoagulant rodenticides, strychnine, 4-aminopyridine, starlicide, and salts revealed none of these compounds; however, desmethylbromethalin was detected by high-performance liquid chromatography-tandem mass spectrometry. Other tissues were subsequently analyzed; the mesenteric and perirenal adipose tissues contained desmethylbromethalin. Desmethylbromethalin is the active metabolite of bromethalin, uncouples oxidative phosphorylation, and results in cerebral edema. Bromethalin is a rodenticide that is visually indistinguishable from many other rodenticides, making identification of poisonings by appearance alone nearly impossible. Based on the pathological and toxicological findings, a diagnosis of bromethalin toxicosis was established. In cases of wildlife species with unknown deaths or inconsistent clinical signs with normal or minimal histological findings, bromethalin toxicosis should be considered as a differential. Adipose tissue is the tissue of choice and can be easily harvested from a live or deceased animal to help confirm or rule out bromethalin exposure or intoxication.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume26
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Raccoons
Procyon lotor
rodenticides
Poisoning
Rodenticides
poisoning
wildlife
adipose tissue
Adipose Tissue
Toxicology
4-aminopyridine
strychnine
materials testing
brain
anticoagulants
oxidative phosphorylation
Materials Testing
Strychnine
4-Aminopyridine
edema

Keywords

  • Bromethalin
  • high-performance liquid chromatography-tandem mass spectrometry
  • neurotoxic
  • poisoning
  • raccoons
  • rodenticide
  • wildlife

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Bromethalin poisoning in a raccoon (Procyon lotor) : Diagnostic considerations and relevance to nontarget wildlife. / Bautista, Adrienne C.; Woods, Leslie; Filigenzi, Mike S.; Puschner, Birgit.

In: Journal of Veterinary Diagnostic Investigation, Vol. 26, No. 1, 01.2014, p. 154-157.

Research output: Contribution to journalArticle

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