Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome

Jennifer Yuhas, Lisa Cordeiro, Flora Tassone, Elizabeth Ballinger, Andrea Schneider, James M. Long, Edward M. Ornitz, David R Hessl

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalJournal of Autism and Developmental Disorders
Volume41
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • FMR1 gene
  • mGluR5
  • PPI
  • Prepulse inhibition
  • Sensorimotor gating
  • Startle

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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