Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome

Jennifer Yuhas, Lisa Cordeiro, Flora Tassone, Elizabeth Ballinger, Andrea Schneider, James M. Long, Edward M. Ornitz, David R Hessl

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalJournal of Autism and Developmental Disorders
Volume41
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Sensory Gating
Fragile X Syndrome
Autistic Disorder
Neurobiology
Prepulse Inhibition

Keywords

  • FMR1 gene
  • mGluR5
  • PPI
  • Prepulse inhibition
  • Sensorimotor gating
  • Startle

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Brief report : Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome. / Yuhas, Jennifer; Cordeiro, Lisa; Tassone, Flora; Ballinger, Elizabeth; Schneider, Andrea; Long, James M.; Ornitz, Edward M.; Hessl, David R.

In: Journal of Autism and Developmental Disorders, Vol. 41, No. 2, 02.2011, p. 248-253.

Research output: Contribution to journalArticle

Yuhas, Jennifer ; Cordeiro, Lisa ; Tassone, Flora ; Ballinger, Elizabeth ; Schneider, Andrea ; Long, James M. ; Ornitz, Edward M. ; Hessl, David R. / Brief report : Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome. In: Journal of Autism and Developmental Disorders. 2011 ; Vol. 41, No. 2. pp. 248-253.
@article{e566c1740f934ba5bcd4f3005a768c2f,
title = "Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome",
abstract = "Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.",
keywords = "FMR1 gene, mGluR5, PPI, Prepulse inhibition, Sensorimotor gating, Startle",
author = "Jennifer Yuhas and Lisa Cordeiro and Flora Tassone and Elizabeth Ballinger and Andrea Schneider and Long, {James M.} and Ornitz, {Edward M.} and Hessl, {David R}",
year = "2011",
month = "2",
doi = "10.1007/s10803-010-1040-9",
language = "English (US)",
volume = "41",
pages = "248--253",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Brief report

T2 - Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome

AU - Yuhas, Jennifer

AU - Cordeiro, Lisa

AU - Tassone, Flora

AU - Ballinger, Elizabeth

AU - Schneider, Andrea

AU - Long, James M.

AU - Ornitz, Edward M.

AU - Hessl, David R

PY - 2011/2

Y1 - 2011/2

N2 - Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.

AB - Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.

KW - FMR1 gene

KW - mGluR5

KW - PPI

KW - Prepulse inhibition

KW - Sensorimotor gating

KW - Startle

UR - http://www.scopus.com/inward/record.url?scp=78751644468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751644468&partnerID=8YFLogxK

U2 - 10.1007/s10803-010-1040-9

DO - 10.1007/s10803-010-1040-9

M3 - Article

C2 - 20521090

AN - SCOPUS:78751644468

VL - 41

SP - 248

EP - 253

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 2

ER -