Abstract
Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 248-253 |
| Number of pages | 6 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2011 |
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Keywords
- FMR1 gene
- mGluR5
- PPI
- Prepulse inhibition
- Sensorimotor gating
- Startle
ASJC Scopus subject areas
- Developmental and Educational Psychology
Cite this
Brief report : Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome. / Yuhas, Jennifer; Cordeiro, Lisa; Tassone, Flora; Ballinger, Elizabeth; Schneider, Andrea; Long, James M.; Ornitz, Edward M.; Hessl, David R.
In: Journal of Autism and Developmental Disorders, Vol. 41, No. 2, 02.2011, p. 248-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brief report
T2 - Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome
AU - Yuhas, Jennifer
AU - Cordeiro, Lisa
AU - Tassone, Flora
AU - Ballinger, Elizabeth
AU - Schneider, Andrea
AU - Long, James M.
AU - Ornitz, Edward M.
AU - Hessl, David R
PY - 2011/2
Y1 - 2011/2
N2 - Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
AB - Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
KW - FMR1 gene
KW - mGluR5
KW - PPI
KW - Prepulse inhibition
KW - Sensorimotor gating
KW - Startle
UR - http://www.scopus.com/inward/record.url?scp=78751644468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751644468&partnerID=8YFLogxK
U2 - 10.1007/s10803-010-1040-9
DO - 10.1007/s10803-010-1040-9
M3 - Article
C2 - 20521090
AN - SCOPUS:78751644468
VL - 41
SP - 248
EP - 253
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 2
ER -