Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome

Jennifer Yuhas, Lisa Cordeiro, Flora Tassone, Elizabeth Ballinger, Andrea Schneider, James M. Long, Edward M. Ornitz, David R Hessl

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalJournal of Autism and Developmental Disorders
Volume41
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • FMR1 gene
  • mGluR5
  • PPI
  • Prepulse inhibition
  • Sensorimotor gating
  • Startle

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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