Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome

Jennifer Yuhas; Lisa Cordeiro; Flora Tassone; Elizabeth Ballinger; Andrea Schneider; James M. Long; Edward M. Ornitz; David R Hessl

doi:10.1007/s10803-010-1040-9

Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome

Jennifer Yuhas, Lisa Cordeiro, Flora Tassone, Elizabeth Ballinger, Andrea Schneider, James M. Long, Edward M. Ornitz, David R Hessl

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.

Original language	English (US)
Pages (from-to)	248-253
Number of pages	6
Journal	Journal of Autism and Developmental Disorders
Volume	41
Issue number	2
DOIs	https://doi.org/10.1007/s10803-010-1040-9
State	Published - Feb 2011

Keywords

FMR1 gene
mGluR5
PPI
Prepulse inhibition
Sensorimotor gating
Startle

ASJC Scopus subject areas

Developmental and Educational Psychology

Access to Document

10.1007/s10803-010-1040-9

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Brief report : Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome. / Yuhas, Jennifer; Cordeiro, Lisa; Tassone, Flora; Ballinger, Elizabeth; Schneider, Andrea; Long, James M.; Ornitz, Edward M.; Hessl, David R.

In: Journal of Autism and Developmental Disorders, Vol. 41, No. 2, 02.2011, p. 248-253.

Research output: Contribution to journal › Article › peer-review

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