Abstract
Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 248-253 |
| Number of pages | 6 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2011 |
Keywords
- FMR1 gene
- mGluR5
- PPI
- Prepulse inhibition
- Sensorimotor gating
- Startle
ASJC Scopus subject areas
- Developmental and Educational Psychology
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Yuhas, J., Cordeiro, L., Tassone, F., Ballinger, E., Schneider, A., Long, J. M., Ornitz, E. M., & Hessl, D. R. (2011). Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome. Journal of Autism and Developmental Disorders, 41(2), 248-253. https://doi.org/10.1007/s10803-010-1040-9