Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: A clinical trial

Stephen Bent, Kiah Bertoglio, Paul Ashwood, Edward Nemeth, Robert L. Hendren

Research output: Contribution to journalArticle

15 Scopus citations


We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes.

Original languageEnglish (US)
Pages (from-to)1127-1132
Number of pages6
JournalJournal of Autism and Developmental Disorders
Issue number6
StatePublished - Jun 2012



  • Alternative therapy
  • Autism
  • Clinical trial

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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