Breast Tissue Differentiation Using Arterial Spin Tagging

David C. Zhu, Michael H. Buonocore

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


An arterial spin tagging (AST) pulse sequence has been developed to measure T1 and relative blood perfusion. This full sequence is composed of three sequences: selective tagging, nonselective tagging, and nontagging. Perfusion quantification error resulting from imperfect inversion and acquisition slice profiles has been addressed in the literature. In this work, the error is reduced through the application of optimized Shinnar-Le Roux (SLR) RF pulses and a semi-log linear regression data-processing technique. A threshold approach based on the breast tissue T1 and relative blood perfusion is introduced to show that these two parameters can be applied to breast tissue differentiation and potentially to cancer detection.

Original languageEnglish (US)
Pages (from-to)966-975
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number5
StatePublished - Nov 2003


  • Blood flow
  • Breast
  • Perfusion
  • Spin labeling
  • Spin tagging
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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