TY - JOUR
T1 - Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems
AU - Ardeshir, Amir
AU - Narayan, Nicole R.
AU - Méndez-Lagares, Gema
AU - Lu, Ding
AU - Rauch, Marcus
AU - Huang, Yong
AU - Van Rompay, Koen K A
AU - Lynch, Susan V.
AU - Hartigan-O'Connor, Dennis
PY - 2014/9/3
Y1 - 2014/9/3
N2 - Diet has a strong influence on the intestinal microbiota in both humans and animal models. It is well established that microbial colonization is required for normal development of the immune system and that specific microbial constituents prompt the differentiation or expansion of certain immune cell subsets. Nonetheless, it has been unclear how profoundly diet might shape the primate immune system or how durable the influence might be. We show that breast-fed and bottle-fed infant rhesus macaques develop markedly different immune systems, which remain different 6 months after weaning when the animals begin receiving identical diets. In particular, breast-fed infants develop robust populations of memory T cells as well as T helper 17 (TH17) cells within the memory pool, whereas bottle-fed infants do not. These findings may partly explain the variation in human susceptibility to conditions with an immune basis, as well as the variable protection against certain infectious diseases.
AB - Diet has a strong influence on the intestinal microbiota in both humans and animal models. It is well established that microbial colonization is required for normal development of the immune system and that specific microbial constituents prompt the differentiation or expansion of certain immune cell subsets. Nonetheless, it has been unclear how profoundly diet might shape the primate immune system or how durable the influence might be. We show that breast-fed and bottle-fed infant rhesus macaques develop markedly different immune systems, which remain different 6 months after weaning when the animals begin receiving identical diets. In particular, breast-fed infants develop robust populations of memory T cells as well as T helper 17 (TH17) cells within the memory pool, whereas bottle-fed infants do not. These findings may partly explain the variation in human susceptibility to conditions with an immune basis, as well as the variable protection against certain infectious diseases.
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U2 - 10.1126/scitranslmed.3008791
DO - 10.1126/scitranslmed.3008791
M3 - Article
C2 - 25186175
AN - SCOPUS:84907289341
VL - 6
JO - Science Translational Medicine
JF - Science Translational Medicine
SN - 1946-6234
IS - 252
M1 - 252ra120
ER -