Breaking the central dogma by RNA editing

Olena Maydanovych, Peter A. Beal

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

This review covers the advances in the understanding of the structure, mechanism, regulation, and biological functions of the ADAR (adenosine deaminases that act on ribonucleic acid (RNA) enzymes published in the last five years. Topics discussed include (1) RNA editing by adenosine deamination and its consequences in vivo, (2) ADARs: Enzymes responsible for adenosine to inosine RNA editing and (3) relationship between RNA editing and the microRNA/RNA interface pathways.

Original languageEnglish (US)
Pages (from-to)3397-3411
Number of pages15
JournalChemical Reviews
Volume106
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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    Maydanovych, O., & Beal, P. A. (2006). Breaking the central dogma by RNA editing. Chemical Reviews, 106(8), 3397-3411. https://doi.org/10.1021/cr050314a