TY - JOUR
T1 - Breach of tolerance
T2 - Primary biliary cirrhosis
AU - Wang, Lifeng
AU - Wang, Fu Sheng
AU - Chang, Christopher
AU - Gershwin, M. Eric
PY - 2014
Y1 - 2014
N2 - In primary biliary cirrhosis (PBC), the breach of tolerance that leads to active disease involves a disruption in several layers of control, including central tolerance, peripheral anergy, a liver tolerance effect, and the action of T regulatory cells and their related cytokines. Each of these control mechanisms plays a role in preventing an immune response against self, but all of them act in concert to generate effective protection against autoimmunity without compromising the ability of the host immune system to mount an effective response to pathogens. At the same time, genetic susceptibility, environmental factors, including infection agents and xenobiotics, play important roles in breach of tolerance in the development of PBC.
AB - In primary biliary cirrhosis (PBC), the breach of tolerance that leads to active disease involves a disruption in several layers of control, including central tolerance, peripheral anergy, a liver tolerance effect, and the action of T regulatory cells and their related cytokines. Each of these control mechanisms plays a role in preventing an immune response against self, but all of them act in concert to generate effective protection against autoimmunity without compromising the ability of the host immune system to mount an effective response to pathogens. At the same time, genetic susceptibility, environmental factors, including infection agents and xenobiotics, play important roles in breach of tolerance in the development of PBC.
KW - antimitochondrial antibodies
KW - apoptosis
KW - autoreactive T cells
KW - liver-tolerance effect
KW - pyruvate dehydrogenase complex
UR - http://www.scopus.com/inward/record.url?scp=84905011139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905011139&partnerID=8YFLogxK
U2 - 10.1055/s-0034-1383729
DO - 10.1055/s-0034-1383729
M3 - Article
C2 - 25057953
AN - SCOPUS:84905011139
VL - 34
SP - 297
EP - 317
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
SN - 0272-8087
IS - 3
ER -