Brainstem auditory evoked potential interwave intervals are prolonged in vitamin B-6-deficient cats

P. S. Buckmaster, T. A. Holliday, S. C. Bai, Quinton Rogers

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Vitamin B-6 deficiency has been reported to produce behavioral, neurophysiological and neuropathological abnormalities in a variety of species. In this investigation we used brainstem auditory evoked potentials (BAEP) to determine if vitamin B-6 deficiency in cats affected peripheral and brainstem auditory pathways. Brainstem auditory evoked potentials were recorded from growing cats as they developed vitamin B-6 deficiency, which was confirmed using clinical, hematological and urinary criteria. The BAEP interwave intervals measured from early (wave 1 or 1(N)) to late waves (5(N)) or from middle (wave 3) to late waves increased significantly, whereas interwave intervals from early to middle waves did not differ significantly. These results indicate that vitamin B-6 deficiency affects one or more structures of the brainstem that generate the later parts of the BAEP. The finding of prolonged interwave intervals in vitamin B-6-deficient animals is consistent with slowed axonal conduction velocity secondary to defective myelination. Recording BAEP provided a noninvasive means of detecting effects of vitamin B-6 deficiency on specific parts of the central nervous system.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalJournal of Nutrition
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes


  • brainstem auditory evoked potentials
  • cats
  • development
  • vitamin B-6 deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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