Brainstem auditory evoked potential interwave intervals are prolonged in vitamin B-6-deficient cats

P. S. Buckmaster, T. A. Holliday, S. C. Bai, Quinton Rogers

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Vitamin B-6 deficiency has been reported to produce behavioral, neurophysiological and neuropathological abnormalities in a variety of species. In this investigation we used brainstem auditory evoked potentials (BAEP) to determine if vitamin B-6 deficiency in cats affected peripheral and brainstem auditory pathways. Brainstem auditory evoked potentials were recorded from growing cats as they developed vitamin B-6 deficiency, which was confirmed using clinical, hematological and urinary criteria. The BAEP interwave intervals measured from early (wave 1 or 1(N)) to late waves (5(N)) or from middle (wave 3) to late waves increased significantly, whereas interwave intervals from early to middle waves did not differ significantly. These results indicate that vitamin B-6 deficiency affects one or more structures of the brainstem that generate the later parts of the BAEP. The finding of prolonged interwave intervals in vitamin B-6-deficient animals is consistent with slowed axonal conduction velocity secondary to defective myelination. Recording BAEP provided a noninvasive means of detecting effects of vitamin B-6 deficiency on specific parts of the central nervous system.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalJournal of Nutrition
Volume123
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Vitamin B 6 Deficiency
Vitamin B 6
Brain Stem Auditory Evoked Potentials
Cats
Brain Stem
Auditory Pathways
Central Nervous System

Keywords

  • brainstem auditory evoked potentials
  • cats
  • development
  • vitamin B-6 deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Brainstem auditory evoked potential interwave intervals are prolonged in vitamin B-6-deficient cats. / Buckmaster, P. S.; Holliday, T. A.; Bai, S. C.; Rogers, Quinton.

In: Journal of Nutrition, Vol. 123, No. 1, 01.01.1993, p. 20-26.

Research output: Contribution to journalArticle

Buckmaster, P. S. ; Holliday, T. A. ; Bai, S. C. ; Rogers, Quinton. / Brainstem auditory evoked potential interwave intervals are prolonged in vitamin B-6-deficient cats. In: Journal of Nutrition. 1993 ; Vol. 123, No. 1. pp. 20-26.
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