Brain perfusion imaging predicts survival in Alzheimer's disease

William J. Jagust, Mary N. Haan, Bruce R Reed, Jamie L. Eberling

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: The variability of disease course in patients diagnosed with AD makes prediction of survival difficult, despite the identification of numerous predictors to date. This study evaluated the predictive utility of measurements of regional cerebral blood flow (rCBF) obtained with SPECT in a group of AD patients. Methods: Fifty AD patients were studied with SPECT and followed longitudinally. SPECT measures of relative rCBF were calculated by measuring radioactivity densities in dorsolateral frontal, orbitofrontal, temporal, and parietal cortex normalized to occipital cortical radioactivity density. Subjects were classified into three tertiles of rCBF ratios for each region. These rCBF ratios were used as predictors of survival in life-table and proportional hazard models to predict survival. Results: Right parietal rCBF was a significant predictor of survival in the life-table analysis, with subjects in the lowest tertile having shortest survivals. No other brain region was a significant predictor of survival. In a proportional hazards model when a variety of other potential predictors were accounted for, right parietal rCBF ratio remained a significant predictor. Conclusions: These results demonstrate that brain perfusion in the right parietal lobe is a significant predictor of survival in patients with AD even when other predictors are taken into consideration. This suggests that SPECT perfusion imaging may provide additional useful information on disease prognosis in AD.

Original languageEnglish (US)
Pages (from-to)1009-1013
Number of pages5
JournalNeurology
Volume51
Issue number4
StatePublished - Oct 1998

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Cerebrovascular Circulation
Perfusion Imaging
Neuroimaging
Regional Blood Flow
Alzheimer Disease
Survival
Single-Photon Emission-Computed Tomography
Parietal Lobe
Life Tables
Proportional Hazards Models
Radioactivity
Brain
Frontal Lobe
Temporal Lobe
Prefrontal Cortex
Perfusion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jagust, W. J., Haan, M. N., Reed, B. R., & Eberling, J. L. (1998). Brain perfusion imaging predicts survival in Alzheimer's disease. Neurology, 51(4), 1009-1013.

Brain perfusion imaging predicts survival in Alzheimer's disease. / Jagust, William J.; Haan, Mary N.; Reed, Bruce R; Eberling, Jamie L.

In: Neurology, Vol. 51, No. 4, 10.1998, p. 1009-1013.

Research output: Contribution to journalArticle

Jagust, WJ, Haan, MN, Reed, BR & Eberling, JL 1998, 'Brain perfusion imaging predicts survival in Alzheimer's disease', Neurology, vol. 51, no. 4, pp. 1009-1013.
Jagust WJ, Haan MN, Reed BR, Eberling JL. Brain perfusion imaging predicts survival in Alzheimer's disease. Neurology. 1998 Oct;51(4):1009-1013.
Jagust, William J. ; Haan, Mary N. ; Reed, Bruce R ; Eberling, Jamie L. / Brain perfusion imaging predicts survival in Alzheimer's disease. In: Neurology. 1998 ; Vol. 51, No. 4. pp. 1009-1013.
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