Brain morphology in older African Americans, caribbean hispanics, and whites from northern Manhattan

Adam M. Brickman, Nicole Schupf, Jennifer J. Manly, José A. Luchsinger, Howard Andrews, Ming X. Tang, Christiane Reitz, Scott A. Small, Richard Mayeux, Charles DeCarli, Truman R. Brown

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Background: Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease. Objective: To examine the effects of age, sex, race/ethnicity, and vascular disease history on measures of brain morphology, including relative brain volume, ventricular volume, hippocampus and entorhinal cortex volumes, and white matter hyperintensity (WMH) burden, in a large community-based cohort of racially/ethnically diverse older adults without dementia. Design: The associations of age, sex, race/ethnicity, and self-reported vascular disease history with brain morphology were examined in a cross-sectional study using multiple linear regression analyses. Sex x race/ethnicity interactions were also considered. Setting: The Washington Heights-Inwood Columbia Aging Project, a community-based epidemiological study of older adults from 3 racial/ethnic groups (white, Hispanic, and African American) from northern Manhattan. Participants: Beginning in 2003, high-resolution quantitative magnetic resonance (MR) images were acquired in 769 participants without dementia. Main Outcome Measures: Relative brain volume (total brain volume/intracranial volume), ventricular volume, and hippocampus and entorhinal cortex volumes were derived manually on high-resolution MR images. White matter hyperintensities were quantified semiautomatically on fluid-attenuated inversion recovery-T2-weighted MR images. Results: Older age was associated with decreased relative brain volume and with increased ventricular and WMH volumes. Hispanic and African American participants had larger relative brain volumes and more severe WMH burden than white participants, but the associations of these variables with age were similar across racial/ethnic groups. Compared with men, women had larger relative brain volumes. Vascular disease was associated with smaller relative brain volume and with higher WMH burden, particularly among African Americans. Conclusions: Older age and vascular disease, particularly among African Americans, are associated with increased brain atrophy and WMH burden. African American and Hispanic subjects have larger relative brain volumes and more WMH than white subjects. Racial/ethnic group differences in WMH severity seem to be partially attributable to differences in vascular disease. Future work will focus on the determinants and cognitive correlates of these differences.

Original languageEnglish (US)
Pages (from-to)1053-1061
Number of pages9
JournalArchives of Neurology
Volume65
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Hispanic Americans
African Americans
Brain
Vascular Diseases
Ethnic Groups
Entorhinal Cortex
Magnetic Resonance Spectroscopy
Dementia
Manhattan
Hippocampus
Cerebrovascular Disorders
White Matter
Atrophy
Epidemiologic Studies
Linear Models
Cross-Sectional Studies
Regression Analysis
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brickman, A. M., Schupf, N., Manly, J. J., Luchsinger, J. A., Andrews, H., Tang, M. X., ... Brown, T. R. (2008). Brain morphology in older African Americans, caribbean hispanics, and whites from northern Manhattan. Archives of Neurology, 65(8), 1053-1061. https://doi.org/10.1001/archneur.65.8.1053

Brain morphology in older African Americans, caribbean hispanics, and whites from northern Manhattan. / Brickman, Adam M.; Schupf, Nicole; Manly, Jennifer J.; Luchsinger, José A.; Andrews, Howard; Tang, Ming X.; Reitz, Christiane; Small, Scott A.; Mayeux, Richard; DeCarli, Charles; Brown, Truman R.

In: Archives of Neurology, Vol. 65, No. 8, 08.2008, p. 1053-1061.

Research output: Contribution to journalArticle

Brickman, AM, Schupf, N, Manly, JJ, Luchsinger, JA, Andrews, H, Tang, MX, Reitz, C, Small, SA, Mayeux, R, DeCarli, C & Brown, TR 2008, 'Brain morphology in older African Americans, caribbean hispanics, and whites from northern Manhattan', Archives of Neurology, vol. 65, no. 8, pp. 1053-1061. https://doi.org/10.1001/archneur.65.8.1053
Brickman, Adam M. ; Schupf, Nicole ; Manly, Jennifer J. ; Luchsinger, José A. ; Andrews, Howard ; Tang, Ming X. ; Reitz, Christiane ; Small, Scott A. ; Mayeux, Richard ; DeCarli, Charles ; Brown, Truman R. / Brain morphology in older African Americans, caribbean hispanics, and whites from northern Manhattan. In: Archives of Neurology. 2008 ; Vol. 65, No. 8. pp. 1053-1061.
@article{0994d8cfbdbe49e188b58846aadaa5d5,
title = "Brain morphology in older African Americans, caribbean hispanics, and whites from northern Manhattan",
abstract = "Background: Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease. Objective: To examine the effects of age, sex, race/ethnicity, and vascular disease history on measures of brain morphology, including relative brain volume, ventricular volume, hippocampus and entorhinal cortex volumes, and white matter hyperintensity (WMH) burden, in a large community-based cohort of racially/ethnically diverse older adults without dementia. Design: The associations of age, sex, race/ethnicity, and self-reported vascular disease history with brain morphology were examined in a cross-sectional study using multiple linear regression analyses. Sex x race/ethnicity interactions were also considered. Setting: The Washington Heights-Inwood Columbia Aging Project, a community-based epidemiological study of older adults from 3 racial/ethnic groups (white, Hispanic, and African American) from northern Manhattan. Participants: Beginning in 2003, high-resolution quantitative magnetic resonance (MR) images were acquired in 769 participants without dementia. Main Outcome Measures: Relative brain volume (total brain volume/intracranial volume), ventricular volume, and hippocampus and entorhinal cortex volumes were derived manually on high-resolution MR images. White matter hyperintensities were quantified semiautomatically on fluid-attenuated inversion recovery-T2-weighted MR images. Results: Older age was associated with decreased relative brain volume and with increased ventricular and WMH volumes. Hispanic and African American participants had larger relative brain volumes and more severe WMH burden than white participants, but the associations of these variables with age were similar across racial/ethnic groups. Compared with men, women had larger relative brain volumes. Vascular disease was associated with smaller relative brain volume and with higher WMH burden, particularly among African Americans. Conclusions: Older age and vascular disease, particularly among African Americans, are associated with increased brain atrophy and WMH burden. African American and Hispanic subjects have larger relative brain volumes and more WMH than white subjects. Racial/ethnic group differences in WMH severity seem to be partially attributable to differences in vascular disease. Future work will focus on the determinants and cognitive correlates of these differences.",
author = "Brickman, {Adam M.} and Nicole Schupf and Manly, {Jennifer J.} and Luchsinger, {Jos{\'e} A.} and Howard Andrews and Tang, {Ming X.} and Christiane Reitz and Small, {Scott A.} and Richard Mayeux and Charles DeCarli and Brown, {Truman R.}",
year = "2008",
month = "8",
doi = "10.1001/archneur.65.8.1053",
language = "English (US)",
volume = "65",
pages = "1053--1061",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "8",

}

TY - JOUR

T1 - Brain morphology in older African Americans, caribbean hispanics, and whites from northern Manhattan

AU - Brickman, Adam M.

AU - Schupf, Nicole

AU - Manly, Jennifer J.

AU - Luchsinger, José A.

AU - Andrews, Howard

AU - Tang, Ming X.

AU - Reitz, Christiane

AU - Small, Scott A.

AU - Mayeux, Richard

AU - DeCarli, Charles

AU - Brown, Truman R.

PY - 2008/8

Y1 - 2008/8

N2 - Background: Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease. Objective: To examine the effects of age, sex, race/ethnicity, and vascular disease history on measures of brain morphology, including relative brain volume, ventricular volume, hippocampus and entorhinal cortex volumes, and white matter hyperintensity (WMH) burden, in a large community-based cohort of racially/ethnically diverse older adults without dementia. Design: The associations of age, sex, race/ethnicity, and self-reported vascular disease history with brain morphology were examined in a cross-sectional study using multiple linear regression analyses. Sex x race/ethnicity interactions were also considered. Setting: The Washington Heights-Inwood Columbia Aging Project, a community-based epidemiological study of older adults from 3 racial/ethnic groups (white, Hispanic, and African American) from northern Manhattan. Participants: Beginning in 2003, high-resolution quantitative magnetic resonance (MR) images were acquired in 769 participants without dementia. Main Outcome Measures: Relative brain volume (total brain volume/intracranial volume), ventricular volume, and hippocampus and entorhinal cortex volumes were derived manually on high-resolution MR images. White matter hyperintensities were quantified semiautomatically on fluid-attenuated inversion recovery-T2-weighted MR images. Results: Older age was associated with decreased relative brain volume and with increased ventricular and WMH volumes. Hispanic and African American participants had larger relative brain volumes and more severe WMH burden than white participants, but the associations of these variables with age were similar across racial/ethnic groups. Compared with men, women had larger relative brain volumes. Vascular disease was associated with smaller relative brain volume and with higher WMH burden, particularly among African Americans. Conclusions: Older age and vascular disease, particularly among African Americans, are associated with increased brain atrophy and WMH burden. African American and Hispanic subjects have larger relative brain volumes and more WMH than white subjects. Racial/ethnic group differences in WMH severity seem to be partially attributable to differences in vascular disease. Future work will focus on the determinants and cognitive correlates of these differences.

AB - Background: Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease. Objective: To examine the effects of age, sex, race/ethnicity, and vascular disease history on measures of brain morphology, including relative brain volume, ventricular volume, hippocampus and entorhinal cortex volumes, and white matter hyperintensity (WMH) burden, in a large community-based cohort of racially/ethnically diverse older adults without dementia. Design: The associations of age, sex, race/ethnicity, and self-reported vascular disease history with brain morphology were examined in a cross-sectional study using multiple linear regression analyses. Sex x race/ethnicity interactions were also considered. Setting: The Washington Heights-Inwood Columbia Aging Project, a community-based epidemiological study of older adults from 3 racial/ethnic groups (white, Hispanic, and African American) from northern Manhattan. Participants: Beginning in 2003, high-resolution quantitative magnetic resonance (MR) images were acquired in 769 participants without dementia. Main Outcome Measures: Relative brain volume (total brain volume/intracranial volume), ventricular volume, and hippocampus and entorhinal cortex volumes were derived manually on high-resolution MR images. White matter hyperintensities were quantified semiautomatically on fluid-attenuated inversion recovery-T2-weighted MR images. Results: Older age was associated with decreased relative brain volume and with increased ventricular and WMH volumes. Hispanic and African American participants had larger relative brain volumes and more severe WMH burden than white participants, but the associations of these variables with age were similar across racial/ethnic groups. Compared with men, women had larger relative brain volumes. Vascular disease was associated with smaller relative brain volume and with higher WMH burden, particularly among African Americans. Conclusions: Older age and vascular disease, particularly among African Americans, are associated with increased brain atrophy and WMH burden. African American and Hispanic subjects have larger relative brain volumes and more WMH than white subjects. Racial/ethnic group differences in WMH severity seem to be partially attributable to differences in vascular disease. Future work will focus on the determinants and cognitive correlates of these differences.

UR - http://www.scopus.com/inward/record.url?scp=49449093536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49449093536&partnerID=8YFLogxK

U2 - 10.1001/archneur.65.8.1053

DO - 10.1001/archneur.65.8.1053

M3 - Article

C2 - 18695055

AN - SCOPUS:49449093536

VL - 65

SP - 1053

EP - 1061

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 8

ER -