Brain morphology in nonsyndromic unicoronal craniosynostosis

Kristina Aldridge, Alex A. Kane, Jeffrey L. Marsh, Jayesh Panchal, Simeon Boyd, Peng Yan, Daniel Govier, Warda Ahmad, Joan T. Richtsmeier

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Studies of isolated craniosynostosis have shown biomechanical and biochemical influences on the craniofacial phenotype, resulting from both genetic and epigenetic factors. Much less attention has been directed toward the morphology of the brain, despite the interactive nature of the developing skull and developing brain. The aim of this study is to define the morphology of the brain in nonsyndromic unilateral coronal synostosis (UCS) in order to form more complete hypotheses about the cause of craniosynostosis. Landmark coordinate data were collected from 3D magnetic resonance image reconstructions of the brain in a sample of UCS patients and an age-matched morphologically normal cohort. These data were analyzed using Euclidean distance matrix analysis. The results of our study demonstrate that despite the basic similarity of overall shape of the brain and skull in UCS, the effects of craniosynostosis on the brain are not localized to structures immediately adjacent to the fused suture or to the endocranial surface of the skull. Rather, alterations are observed throughout the volume of the brain, with subcortical structures altered in conjunction with cortical changes. These results indicate that the morphological correlates are different for brain and skull and suggest that there is a large degree of independence in the developmental trajectories of the brain and skull.

Original languageEnglish (US)
Pages (from-to)690-698
Number of pages9
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume285
Issue number2
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

Craniosynostoses
brain
skull
Brain
Skull
Computer-Assisted Image Processing
sutures
Epigenomics
epigenetics
Sutures
trajectories
phenotype
Magnetic Resonance Spectroscopy
trajectory
Phenotype
matrix

Keywords

  • Brain
  • Craniosynostosis
  • Development
  • Morphometrics
  • Suture

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Brain morphology in nonsyndromic unicoronal craniosynostosis. / Aldridge, Kristina; Kane, Alex A.; Marsh, Jeffrey L.; Panchal, Jayesh; Boyd, Simeon; Yan, Peng; Govier, Daniel; Ahmad, Warda; Richtsmeier, Joan T.

In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, Vol. 285, No. 2, 08.2005, p. 690-698.

Research output: Contribution to journalArticle

Aldridge, K, Kane, AA, Marsh, JL, Panchal, J, Boyd, S, Yan, P, Govier, D, Ahmad, W & Richtsmeier, JT 2005, 'Brain morphology in nonsyndromic unicoronal craniosynostosis', Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, vol. 285, no. 2, pp. 690-698. https://doi.org/10.1002/ar.a.20201
Aldridge, Kristina ; Kane, Alex A. ; Marsh, Jeffrey L. ; Panchal, Jayesh ; Boyd, Simeon ; Yan, Peng ; Govier, Daniel ; Ahmad, Warda ; Richtsmeier, Joan T. / Brain morphology in nonsyndromic unicoronal craniosynostosis. In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 2005 ; Vol. 285, No. 2. pp. 690-698.
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