Brain moderators supporting the relationship between depressive mood and pain

Adrienne L. Adler-Neal, Nichole M. Emerson, Suzan R. Farris, Youngkyoo Jung, Robert C. Coghill, Fadel Zeidan

Research output: Contribution to journalArticle

Abstract

Pain and depressive mood commonly exhibit a comorbid relationship. Yet, the brain mechanisms that moderate the relationship between dysphoric mood and pain remain unknown. An exploratory analysis of functional magnetic resonance imaging, behavioral, and psychophysical data was collected from a previous study in 76 healthy, nondepressed, and pain-free individuals. Participants completed the Beck Depression Inventory-II (BDI), a measure of negative mood/depressive symptomology, and provided pain intensity and pain unpleasantness ratings in response to noxious heat (49°C) during perfusion-based, arterial spin-labeled functional magnetic resonance imaging. Moderation analyses were conducted to determine neural mechanisms involved in facilitating the hypothesized relationship between depressive mood and pain sensitivity. Higher BDI-II scores were positively associated with pain intensity (R = 0.10; P = 0.006) and pain unpleasantness (R = 0.12; P = 0.003) ratings. There was a high correlation between pain intensity and unpleasantness ratings (r = 0.94; P < 0.001); thus, brain moderation analyses were focused on pain intensity ratings. Individuals with higher levels of depressive mood exhibited heightened sensitivity to experimental pain. Greater activation in regions supporting the evaluation of pain (ventrolateral prefrontal cortex; anterior insula) and sensory-discrimination (secondary somatosensory cortex; posterior insula) moderated the relationship between higher BDI-II scores and pain intensity ratings. This study demonstrates that executive-level and sensory-discriminative brain mechanisms play a multimodal role in facilitating the bidirectional relationship between negative mood and pain.

Original languageEnglish (US)
Pages (from-to)2028-2035
Number of pages8
JournalPain
Volume160
Issue number9
DOIs
StatePublished - Sep 1 2019
Externally publishedYes

Fingerprint

Pain
Brain
Depression
Equipment and Supplies
Magnetic Resonance Imaging
Somatosensory Cortex
Prefrontal Cortex
Perfusion
Hot Temperature

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Adler-Neal, A. L., Emerson, N. M., Farris, S. R., Jung, Y., Coghill, R. C., & Zeidan, F. (2019). Brain moderators supporting the relationship between depressive mood and pain. Pain, 160(9), 2028-2035. https://doi.org/10.1097/j.pain.0000000000001595

Brain moderators supporting the relationship between depressive mood and pain. / Adler-Neal, Adrienne L.; Emerson, Nichole M.; Farris, Suzan R.; Jung, Youngkyoo; Coghill, Robert C.; Zeidan, Fadel.

In: Pain, Vol. 160, No. 9, 01.09.2019, p. 2028-2035.

Research output: Contribution to journalArticle

Adler-Neal, AL, Emerson, NM, Farris, SR, Jung, Y, Coghill, RC & Zeidan, F 2019, 'Brain moderators supporting the relationship between depressive mood and pain', Pain, vol. 160, no. 9, pp. 2028-2035. https://doi.org/10.1097/j.pain.0000000000001595
Adler-Neal AL, Emerson NM, Farris SR, Jung Y, Coghill RC, Zeidan F. Brain moderators supporting the relationship between depressive mood and pain. Pain. 2019 Sep 1;160(9):2028-2035. https://doi.org/10.1097/j.pain.0000000000001595
Adler-Neal, Adrienne L. ; Emerson, Nichole M. ; Farris, Suzan R. ; Jung, Youngkyoo ; Coghill, Robert C. ; Zeidan, Fadel. / Brain moderators supporting the relationship between depressive mood and pain. In: Pain. 2019 ; Vol. 160, No. 9. pp. 2028-2035.
@article{b4f2d5ac2c24495aa2cd89bdbb7bdd9a,
title = "Brain moderators supporting the relationship between depressive mood and pain",
abstract = "Pain and depressive mood commonly exhibit a comorbid relationship. Yet, the brain mechanisms that moderate the relationship between dysphoric mood and pain remain unknown. An exploratory analysis of functional magnetic resonance imaging, behavioral, and psychophysical data was collected from a previous study in 76 healthy, nondepressed, and pain-free individuals. Participants completed the Beck Depression Inventory-II (BDI), a measure of negative mood/depressive symptomology, and provided pain intensity and pain unpleasantness ratings in response to noxious heat (49°C) during perfusion-based, arterial spin-labeled functional magnetic resonance imaging. Moderation analyses were conducted to determine neural mechanisms involved in facilitating the hypothesized relationship between depressive mood and pain sensitivity. Higher BDI-II scores were positively associated with pain intensity (R = 0.10; P = 0.006) and pain unpleasantness (R = 0.12; P = 0.003) ratings. There was a high correlation between pain intensity and unpleasantness ratings (r = 0.94; P < 0.001); thus, brain moderation analyses were focused on pain intensity ratings. Individuals with higher levels of depressive mood exhibited heightened sensitivity to experimental pain. Greater activation in regions supporting the evaluation of pain (ventrolateral prefrontal cortex; anterior insula) and sensory-discrimination (secondary somatosensory cortex; posterior insula) moderated the relationship between higher BDI-II scores and pain intensity ratings. This study demonstrates that executive-level and sensory-discriminative brain mechanisms play a multimodal role in facilitating the bidirectional relationship between negative mood and pain.",
author = "Adler-Neal, {Adrienne L.} and Emerson, {Nichole M.} and Farris, {Suzan R.} and Youngkyoo Jung and Coghill, {Robert C.} and Fadel Zeidan",
year = "2019",
month = "9",
day = "1",
doi = "10.1097/j.pain.0000000000001595",
language = "English (US)",
volume = "160",
pages = "2028--2035",
journal = "Pain",
issn = "0304-3959",
publisher = "Elsevier",
number = "9",

}

TY - JOUR

T1 - Brain moderators supporting the relationship between depressive mood and pain

AU - Adler-Neal, Adrienne L.

AU - Emerson, Nichole M.

AU - Farris, Suzan R.

AU - Jung, Youngkyoo

AU - Coghill, Robert C.

AU - Zeidan, Fadel

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Pain and depressive mood commonly exhibit a comorbid relationship. Yet, the brain mechanisms that moderate the relationship between dysphoric mood and pain remain unknown. An exploratory analysis of functional magnetic resonance imaging, behavioral, and psychophysical data was collected from a previous study in 76 healthy, nondepressed, and pain-free individuals. Participants completed the Beck Depression Inventory-II (BDI), a measure of negative mood/depressive symptomology, and provided pain intensity and pain unpleasantness ratings in response to noxious heat (49°C) during perfusion-based, arterial spin-labeled functional magnetic resonance imaging. Moderation analyses were conducted to determine neural mechanisms involved in facilitating the hypothesized relationship between depressive mood and pain sensitivity. Higher BDI-II scores were positively associated with pain intensity (R = 0.10; P = 0.006) and pain unpleasantness (R = 0.12; P = 0.003) ratings. There was a high correlation between pain intensity and unpleasantness ratings (r = 0.94; P < 0.001); thus, brain moderation analyses were focused on pain intensity ratings. Individuals with higher levels of depressive mood exhibited heightened sensitivity to experimental pain. Greater activation in regions supporting the evaluation of pain (ventrolateral prefrontal cortex; anterior insula) and sensory-discrimination (secondary somatosensory cortex; posterior insula) moderated the relationship between higher BDI-II scores and pain intensity ratings. This study demonstrates that executive-level and sensory-discriminative brain mechanisms play a multimodal role in facilitating the bidirectional relationship between negative mood and pain.

AB - Pain and depressive mood commonly exhibit a comorbid relationship. Yet, the brain mechanisms that moderate the relationship between dysphoric mood and pain remain unknown. An exploratory analysis of functional magnetic resonance imaging, behavioral, and psychophysical data was collected from a previous study in 76 healthy, nondepressed, and pain-free individuals. Participants completed the Beck Depression Inventory-II (BDI), a measure of negative mood/depressive symptomology, and provided pain intensity and pain unpleasantness ratings in response to noxious heat (49°C) during perfusion-based, arterial spin-labeled functional magnetic resonance imaging. Moderation analyses were conducted to determine neural mechanisms involved in facilitating the hypothesized relationship between depressive mood and pain sensitivity. Higher BDI-II scores were positively associated with pain intensity (R = 0.10; P = 0.006) and pain unpleasantness (R = 0.12; P = 0.003) ratings. There was a high correlation between pain intensity and unpleasantness ratings (r = 0.94; P < 0.001); thus, brain moderation analyses were focused on pain intensity ratings. Individuals with higher levels of depressive mood exhibited heightened sensitivity to experimental pain. Greater activation in regions supporting the evaluation of pain (ventrolateral prefrontal cortex; anterior insula) and sensory-discrimination (secondary somatosensory cortex; posterior insula) moderated the relationship between higher BDI-II scores and pain intensity ratings. This study demonstrates that executive-level and sensory-discriminative brain mechanisms play a multimodal role in facilitating the bidirectional relationship between negative mood and pain.

UR - http://www.scopus.com/inward/record.url?scp=85071702730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071702730&partnerID=8YFLogxK

U2 - 10.1097/j.pain.0000000000001595

DO - 10.1097/j.pain.0000000000001595

M3 - Article

C2 - 31095097

AN - SCOPUS:85071702730

VL - 160

SP - 2028

EP - 2035

JO - Pain

JF - Pain

SN - 0304-3959

IS - 9

ER -