Brain mitochondrial uncoupling protein 2 (UCP2): A protective stress signal in neuronal injury

Ingo Bechmann, Sabrina Diano, Craig H Warden, Tamas Bartfai, Robert Nitsch, Tamas L. Horvath

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Mitochondrial uncoupling proteins (UCPs) can dissociate oxidative phosphorylation from respiration, and they appear to be critical for energy balance. One of these proteins, UCP2, is also expressed in neurons of subcortical brain regions of healthy subjects. Here, we report on the protective role of UCP2 in brain injury by revealing its early induction after lesions and its inverse relationship with activation of an apoptotic signal, caspase 3, in wild-type and UCP2 overexpressing transgenic mice.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
JournalBiochemical Pharmacology
Volume64
Issue number3
DOIs
StatePublished - Aug 1 2002

Keywords

  • Brain injury
  • Hippocampus
  • Microglia
  • Mitochondrial uncoupling proteins
  • Neuronal degeneration

ASJC Scopus subject areas

  • Pharmacology

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