Abstract
The differential effects of systemic anoxia on the immature rat brain in two postnatal developmental age groups, group I (1-2 days postnatal) and group II (9-10 days postnatal), were studied utilizing phosphorus-31 nuclear magnetic resonance spectroscopy. While all pups in group I survived the 15- min anoxic period, only half of the pups in group II survived. Brain adenosine triphosphate and intracellular pH of pups in group I remained essentially unchanged throughout the anoxic period, while phosphocreatine and inorganic phosphate were sensitive indicators of anoxia. These parameters were all more drastically affected in group II pups than in group I pups. Group II pups also exhibited a significant increase in phosphomonoester, indicating developmental differences in phospholipid metabolism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 205-212 |
| Number of pages | 8 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 24 |
| Issue number | 2 |
| State | Published - 1992 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Brain maturation and response to anoxia : 31P NMR spectroscopic studies in rat pups. / Suzuki, N.; Kwee, Ingrid; Nakada, T.
In: Magnetic Resonance in Medicine, Vol. 24, No. 2, 1992, p. 205-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain maturation and response to anoxia
T2 - 31P NMR spectroscopic studies in rat pups
AU - Suzuki, N.
AU - Kwee, Ingrid
AU - Nakada, T.
PY - 1992
Y1 - 1992
N2 - The differential effects of systemic anoxia on the immature rat brain in two postnatal developmental age groups, group I (1-2 days postnatal) and group II (9-10 days postnatal), were studied utilizing phosphorus-31 nuclear magnetic resonance spectroscopy. While all pups in group I survived the 15- min anoxic period, only half of the pups in group II survived. Brain adenosine triphosphate and intracellular pH of pups in group I remained essentially unchanged throughout the anoxic period, while phosphocreatine and inorganic phosphate were sensitive indicators of anoxia. These parameters were all more drastically affected in group II pups than in group I pups. Group II pups also exhibited a significant increase in phosphomonoester, indicating developmental differences in phospholipid metabolism.
AB - The differential effects of systemic anoxia on the immature rat brain in two postnatal developmental age groups, group I (1-2 days postnatal) and group II (9-10 days postnatal), were studied utilizing phosphorus-31 nuclear magnetic resonance spectroscopy. While all pups in group I survived the 15- min anoxic period, only half of the pups in group II survived. Brain adenosine triphosphate and intracellular pH of pups in group I remained essentially unchanged throughout the anoxic period, while phosphocreatine and inorganic phosphate were sensitive indicators of anoxia. These parameters were all more drastically affected in group II pups than in group I pups. Group II pups also exhibited a significant increase in phosphomonoester, indicating developmental differences in phospholipid metabolism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026550730&partnerID=8YFLogxK
M3 - Article
C2 - 1569861
AN - SCOPUS:0026550730
VL - 24
SP - 205
EP - 212
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 2
ER -