Brain maturation and response to anoxia: 31P NMR spectroscopic studies in rat pups

N. Suzuki, Ingrid Kwee, T. Nakada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The differential effects of systemic anoxia on the immature rat brain in two postnatal developmental age groups, group I (1-2 days postnatal) and group II (9-10 days postnatal), were studied utilizing phosphorus-31 nuclear magnetic resonance spectroscopy. While all pups in group I survived the 15- min anoxic period, only half of the pups in group II survived. Brain adenosine triphosphate and intracellular pH of pups in group I remained essentially unchanged throughout the anoxic period, while phosphocreatine and inorganic phosphate were sensitive indicators of anoxia. These parameters were all more drastically affected in group II pups than in group I pups. Group II pups also exhibited a significant increase in phosphomonoester, indicating developmental differences in phospholipid metabolism.

Original languageEnglish (US)
Pages (from-to)205-212
Number of pages8
JournalMagnetic Resonance in Medicine
Volume24
Issue number2
StatePublished - 1992

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Phosphocreatine
Brain
Phosphorus
Phospholipids
Magnetic Resonance Spectroscopy
Age Groups
Adenosine Triphosphate
Phosphates
Hypoxia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Brain maturation and response to anoxia : 31P NMR spectroscopic studies in rat pups. / Suzuki, N.; Kwee, Ingrid; Nakada, T.

In: Magnetic Resonance in Medicine, Vol. 24, No. 2, 1992, p. 205-212.

Research output: Contribution to journalArticle

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