Brain Lesions Associated With Clostridium perfringens Type D Epsilon Toxin in a Holstein Heifer Calf

Asli Mete, J. Garcia, J. Ortega, M. Lane, S. Scholes, Francisco A Uzal

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A 6-month-old dairy heifer calf with no premonitory signs was acutely down after the morning feeding and could not rise. On presentation, the heifer was in right lateral recumbency and moribund with opisthotonus and left hind limb paddling. Following euthanasia, gross examination of the brain revealed multifocal loss of gray-white matter distinction and extensive petechiae throughout the brainstem. On histopathological examination, there was striking white matter edema and marked perivascular proteinaceous edema surrounding many arterioles and venules (microangiopathy), mainly in the white matter of the internal capsule, thalamus, midbrain, cerebellum, and cerebellar peduncles. The perivascular neuropil was strongly positive for Alzheimer precursor protein A4. Clostridium perfringens epsilon toxin was detected in the intestinal contents. This is the first report of microangiopathy in postneonatal cattle associated with the detection of epsilon toxin in the intestinal contents.

Original languageEnglish (US)
Pages (from-to)765-768
Number of pages4
JournalVeterinary Pathology
Volume50
Issue number5
DOIs
StatePublished - Sep 2013

Keywords

  • Alzheimer precursor protein
  • APP
  • brain
  • cattle
  • Clostridium perfringens
  • enterotoxemia
  • epsilon toxin
  • ETX
  • microangiopathy

ASJC Scopus subject areas

  • veterinary(all)

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