Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects

A proton magnetic resonance spectroscopy study at 1.5 Tesla

Richard J Maddock, Michael H. Buonocore, Shawn P. Lavoie, Linda E. Copeland, Shawn J. Kile, Anne L. Richards, John M. Ryan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Proton magnetic resonance spectroscopy (1H-MRS) studies showing increased lactate during neural activation support a broader role for lactate in brain energy metabolism than was traditionally recognized. Proton MRS measures of brain lactate responses have been used to study regional brain metabolism in clinical populations. This study examined whether variations in blood glucose influence the lactate response to visual stimulation in the visual cortex. Six subjects were scanned twice, receiving either saline or 21% glucose intravenously. Using 1H-MRS at 1.5 Tesla with a long echo time (TE = 288 ms), the lactate doublet was visible at 1.32 ppm in the visual cortex of all subjects. Lactate increased significantly from resting to visual stimulation. Hyperglycemia had no effect on this increase. The order of the slice-selective gradients for defining the spectroscopy voxel had a pronounced effect on the extent of contamination by signal originating outside the voxel. The results of this preliminary study demonstrate a method for observing a consistent activity-stimulated increase in brain lactate at 1.5 T and show that variations in blood glucose across the normal range have little effect on this response.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume148
Issue number1
DOIs
StatePublished - Nov 22 2006

Fingerprint

Photic Stimulation
Lactic Acid
Fasting
Brain
Visual Cortex
Blood Glucose
Proton Magnetic Resonance Spectroscopy
Hyperglycemia
Energy Metabolism
Protons
Spectrum Analysis
Reference Values
Glucose
Population

Keywords

  • Aerobic
  • Glycolysis
  • Glycolytic
  • Lactic acid
  • PRESS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects : A proton magnetic resonance spectroscopy study at 1.5 Tesla. / Maddock, Richard J; Buonocore, Michael H.; Lavoie, Shawn P.; Copeland, Linda E.; Kile, Shawn J.; Richards, Anne L.; Ryan, John M.

In: Psychiatry Research - Neuroimaging, Vol. 148, No. 1, 22.11.2006, p. 47-54.

Research output: Contribution to journalArticle

Maddock, Richard J ; Buonocore, Michael H. ; Lavoie, Shawn P. ; Copeland, Linda E. ; Kile, Shawn J. ; Richards, Anne L. ; Ryan, John M. / Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects : A proton magnetic resonance spectroscopy study at 1.5 Tesla. In: Psychiatry Research - Neuroimaging. 2006 ; Vol. 148, No. 1. pp. 47-54.
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