Brain isozyme of glycogen phosphorylase: immunohistologicall localization within the central nervous system

Pamela C. Ignacio, Barbara A. Baldwin, Vijaya K. Vijayan, Robert C. Tait, Fredric A Gorin

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

An antibody specific for the predicted carboxyterminal sequence of the human brain isozyme of glycogen phosphorylase (α-1,4-d-glucan: orthophosphate d-glyucosyltransferase, EC 2.4.1.1) was generated to verify the carboxyterminal amino acid sequence of this protein. The isozyme-specific antibody was used to examine the localization of this protein in primate and non-primate brain. The highest levels of the brain isozyme in cerebrum and cerebellum were found in fibrous astrocytes, many with glial processes that appear to terminate upon blood vessels.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalBrain Research
Volume529
Issue number1-2
DOIs
StatePublished - Oct 8 1990

Fingerprint

Glycogen Phosphorylase
Isoenzymes
Central Nervous System
Brain
Antibodies
Cerebrum
Neuroglia
Astrocytes
Cerebellum
Primates
Blood Vessels
Amino Acid Sequence
Proteins
Phosphates

Keywords

  • Brain isozyme
  • Glycogen phosphorylase
  • Immunohistology
  • Primate
  • Rat

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Brain isozyme of glycogen phosphorylase : immunohistologicall localization within the central nervous system. / Ignacio, Pamela C.; Baldwin, Barbara A.; Vijayan, Vijaya K.; Tait, Robert C.; Gorin, Fredric A.

In: Brain Research, Vol. 529, No. 1-2, 08.10.1990, p. 42-49.

Research output: Contribution to journalArticle

Ignacio, Pamela C. ; Baldwin, Barbara A. ; Vijayan, Vijaya K. ; Tait, Robert C. ; Gorin, Fredric A. / Brain isozyme of glycogen phosphorylase : immunohistologicall localization within the central nervous system. In: Brain Research. 1990 ; Vol. 529, No. 1-2. pp. 42-49.
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