Brain imaging evidence of preclinical Alzheimer's disease in normal aging

William Jagust, Amy Gitcho, Felice Sun, Beth Kuczynski, Dan M Mungas, Mary Haan

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


Objective: This study was designed to test the hypothesis that baseline glucose metabolism and medial temporal lobe brain volumes are predictive of cognitive decline in normal older people. Methods: We performed positron emission tomography using [18F] fluorodeoxyglucose and structural magnetic resonance imaging at baseline in 60 cognitively normal community-dwelling older subjects who were part of a longitudinal cohort study. Subjects were followed for a mean of 3.8 years, with approximately annual evaluation of global cognition (the Modified Mini-Mental State Examination) and episodic memory (delayed recall). Baseline brain volumes and glucose metabolism were evaluated in relation to die rate of change in cognitive test scores. Results: Six subjects developed incident dementia or cognitive impairment (converters). Baseline positron emission tomography scans showed regions in left and right angular gyms, left mid-temporal gyms, and left middle frontal gyrus that predicted the rate of change on the Modified Mini-Mental State Examination (p < 0.001). The left hemisphere temporal and parietal regions remained significant when converters were excluded. Both hippocampal (p = 0.03) and entorhinal cortical volumes (p = 0.01) predicted decline on delayed recall over time, and entorhinal cortical volumes remained significant when converters were excluded (p = 0.02). These brain volumes did not predict Modified Mini-Mental State Examination decline. Interpretation: These results indicate that temporal and parietal glucose metabolism predict decline in global cognitive function, and medial temporal brain volumes predict memory decline in normal older people. The anatomical location of these findings suggests detection of precluded Alzheimer's disease pathology.

Original languageEnglish (US)
Pages (from-to)673-681
Number of pages9
JournalAnnals of Neurology
Issue number4
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Neuroscience(all)


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