Brain glutathione levels and age at onset of illness in chronic schizophrenia

Yvonne S. Yang, Richard J Maddock, Junghee Lee, Huailin Zhang, Gerhard Hellemann, Katherine L. Narr, Stephen R. Marder, Michael F. Green

Research output: Contribution to journalArticle

Abstract

Objective:Oxidative stress is implicated in the etiology of schizophrenia, and the antioxidant defense system may be protective in this illness. We examined the major antioxidant glutathione (GSH) in prefrontal brain, and its correlates with clinical and demographic variables, in schizophrenia.Methods:GSH levels were measured in the dorsolateral prefrontal region of 28 patients with chronic schizophrenia using a magnetic resonance spectroscopy sequence specifically adapted for GSH. We examined correlations of GSH levels with age, age at onset of illness, duration of illness, and clinical symptoms.Results:We found a negative correlation between GSH levels and age at onset (r=-.46, p=.015), and a trend-level positive relationship between GSH and duration of illness (r=.34, p=.076).Conclusion:Our findings are consistent with a possible compensatory upregulation of the antioxidant defense system with longer duration of illness, and suggests the antioxidant defense system may play a role in schizophrenia.

Original languageEnglish (US)
JournalActa Neuropsychiatrica
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • age of onset
  • glutathione
  • oxidative stress
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Yang, Y. S., Maddock, R. J., Lee, J., Zhang, H., Hellemann, G., Narr, K. L., Marder, S. R., & Green, M. F. (Accepted/In press). Brain glutathione levels and age at onset of illness in chronic schizophrenia. Acta Neuropsychiatrica. https://doi.org/10.1017/neu.2019.29