Abstract
OBJECTIVE. The purpose of this work was to detect brain developmental abnormalities in Prader-Willi syndrome by using diffusion tensor imaging based on a high-field MRI system. METHODS. Eight patients with Prader-Willi syndrome and 8 age- and gender-matched normal control subjects were examined using a high-field (3.0 T) MRI system. Trace value and fractional anisotropy were assessed simultaneously in multiple representative brain regions: the deep gray matter (putamen, caudate head, and dorsomedial thalamus) and the white matter structures (frontal and parietal white matter, posterior limb of internal capsule, and corpus callosum). RESULTS. In Prader-Willi syndrome patients, trace value was found to be significantly higher in the left frontal white matter and the left dorsomedial thalamus, whereas fractional anisotropy was significantly reduced in the posterior limb of the internal capsule bilaterally, the right frontal white matter, and the splenium of the corpus callosum. The observed diffusivity characteristics indicate developmental abnormalities in these areas, which are highly consistent with the clinical features of Prader-Willi syndrome. CONCLUSIONS. The study provides the first objective evidence that Prader-Willi syndrome patients indeed have developmental abnormalities in specific areas of the brain, providing a new window toward understanding the pathophysiology of Prader-Willi syndrome.
| Original language | English (US) |
|---|---|
| Journal | Pediatrics |
| Volume | 118 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2006 |
Fingerprint
Keywords
- Brain development
- Diffusion tensor imaging
- Fractional anisotropy
- Prader-Willi syndrome
- Trace
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Brain developmental abnormalities in Prader-Willi syndrome detected by diffusion tensor imaging. / Yamada, Kenichi; Matsuzawa, Hitoshi; Uchiyama, Makoto; Kwee, Ingrid; Nakada, Tsutomu.
In: Pediatrics, Vol. 118, No. 2, 08.2006.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain developmental abnormalities in Prader-Willi syndrome detected by diffusion tensor imaging
AU - Yamada, Kenichi
AU - Matsuzawa, Hitoshi
AU - Uchiyama, Makoto
AU - Kwee, Ingrid
AU - Nakada, Tsutomu
PY - 2006/8
Y1 - 2006/8
N2 - OBJECTIVE. The purpose of this work was to detect brain developmental abnormalities in Prader-Willi syndrome by using diffusion tensor imaging based on a high-field MRI system. METHODS. Eight patients with Prader-Willi syndrome and 8 age- and gender-matched normal control subjects were examined using a high-field (3.0 T) MRI system. Trace value and fractional anisotropy were assessed simultaneously in multiple representative brain regions: the deep gray matter (putamen, caudate head, and dorsomedial thalamus) and the white matter structures (frontal and parietal white matter, posterior limb of internal capsule, and corpus callosum). RESULTS. In Prader-Willi syndrome patients, trace value was found to be significantly higher in the left frontal white matter and the left dorsomedial thalamus, whereas fractional anisotropy was significantly reduced in the posterior limb of the internal capsule bilaterally, the right frontal white matter, and the splenium of the corpus callosum. The observed diffusivity characteristics indicate developmental abnormalities in these areas, which are highly consistent with the clinical features of Prader-Willi syndrome. CONCLUSIONS. The study provides the first objective evidence that Prader-Willi syndrome patients indeed have developmental abnormalities in specific areas of the brain, providing a new window toward understanding the pathophysiology of Prader-Willi syndrome.
AB - OBJECTIVE. The purpose of this work was to detect brain developmental abnormalities in Prader-Willi syndrome by using diffusion tensor imaging based on a high-field MRI system. METHODS. Eight patients with Prader-Willi syndrome and 8 age- and gender-matched normal control subjects were examined using a high-field (3.0 T) MRI system. Trace value and fractional anisotropy were assessed simultaneously in multiple representative brain regions: the deep gray matter (putamen, caudate head, and dorsomedial thalamus) and the white matter structures (frontal and parietal white matter, posterior limb of internal capsule, and corpus callosum). RESULTS. In Prader-Willi syndrome patients, trace value was found to be significantly higher in the left frontal white matter and the left dorsomedial thalamus, whereas fractional anisotropy was significantly reduced in the posterior limb of the internal capsule bilaterally, the right frontal white matter, and the splenium of the corpus callosum. The observed diffusivity characteristics indicate developmental abnormalities in these areas, which are highly consistent with the clinical features of Prader-Willi syndrome. CONCLUSIONS. The study provides the first objective evidence that Prader-Willi syndrome patients indeed have developmental abnormalities in specific areas of the brain, providing a new window toward understanding the pathophysiology of Prader-Willi syndrome.
KW - Brain development
KW - Diffusion tensor imaging
KW - Fractional anisotropy
KW - Prader-Willi syndrome
KW - Trace
UR - http://www.scopus.com/inward/record.url?scp=33748419822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748419822&partnerID=8YFLogxK
U2 - 10.1542/peds.2006-0637
DO - 10.1542/peds.2006-0637
M3 - Article
C2 - 16882785
AN - SCOPUS:33748419822
VL - 118
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 2
ER -