Brain atrophy associated with baseline and longitudinal measures of cognition

V. A. Cardenas, L. L. Chao, C. Studholme, K. Yaffe, B. L. Miller, C. Madison, S. T. Buckley, Dan M Mungas, N. Schuff, M. W. Weiner

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


The overall goal was to identify patterns of brain atrophy associated with cognitive impairment and future cognitive decline in non-demented elders. Seventy-one participants were studied with structural MRI and neuropsychological testing at baseline and 1-year follow-up. Deformation-based morphometry was used to examine the relationship between regional baseline brain tissue volume with baseline and longitudinal measures of delayed verbal memory, semantic memory, and executive function. Smaller right hippocampal and entorhinal cortex (ERC) volumes at baseline were associated with worse delayed verbal memory performance at baseline while smaller left ERC volume was associated with greater longitudinal decline. Smaller left superior temporal cortex at baseline was associated with worse semantic memory at baseline, while smaller left temporal white and gray matter volumes were associated with greater semantic memory decline. Increased CSF and smaller frontal lobe volumes were associated with impaired executive function at baseline and greater longitudinal executive decline. These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals.

Original languageEnglish (US)
Pages (from-to)572-580
Number of pages9
JournalNeurobiology of Aging
Issue number4
StatePublished - Apr 2011


  • Brain
  • Cognition
  • Deformation morphometry
  • Executive function
  • Longitudinal
  • Memory
  • MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology


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