Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs

Marc P Kaufman, H. M. Coleridge, J. C G Coleridge, D. G. Baker

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Bradykinin is released in the lungs in asthma and pulmonary anaphylaxis. It has negligible direct bronchoconstrictor effects in humans or dogs, but inhaled as aerosol it causes cough and reflex bronchoconstriction in asthmatics and some normal subjects. The afferent nerves responsible for these reflex effects have not been identified. We recorded vagal impulses in anesthetized dogs to determine whether lung afferents were stimulated by bradykinin. C-fiber endings in the intrapulmonary airways accessible from the systemic circulation were stimulated by bradykinin injected into the left atrium (0.5-1.0 μg/kg) or bronchial artery (1.5 μg), activity increasing 15-fold on average. C-fiber endings accessible from the pulmonary circulation were relatively insensitive to bradykinin. Bradykinin caused a small increase in firing of some rapidly adapting (irritant) receptors, but the affect appeared to be secondary to vascular changes. Bradykinin had variable effects on slowly adapting stretch receptors, but did not stimulate them directly. Thus vagally mediated sensory or reflex effects initiated by bradykinin in the lung are probably due to stimulation of 'bronchial' C-fibers.

Original languageEnglish (US)
Pages (from-to)511-517
Number of pages7
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume48
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Unmyelinated Nerve Fibers
Bradykinin
Dogs
Reflex
Lung
Bronchoconstrictor Agents
Bronchial Arteries
Mechanoreceptors
Pulmonary Circulation
Bronchoconstriction
Irritants
Anaphylaxis
Heart Atria
Aerosols
Cough
Blood Vessels
Asthma

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs. / Kaufman, Marc P; Coleridge, H. M.; Coleridge, J. C G; Baker, D. G.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 48, No. 3, 1980, p. 511-517.

Research output: Contribution to journalArticle

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