BP8, a novel peptide from avian immune system, modulates B cell developments

Xiao Dong Liu, Bin Zhou, Xiuli Feng, Rui Bing Cao, Pu Yan Chen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The bursa of Fabricius (BF) is the key humoral immune organ unique to birds, and is critical for early B-lymphocyte proliferation and differentiation. However, the molecular basis and mechanisms through which the BF regulates B cell development are not fully understood. In this study, we isolated and identified a new bursal peptide (BP8, AGHTKKAP) by RP-HPLC and MALDI-TOF-MS. BP8 promoted colony-forming pre-B formation, bound B cell precursor, regulated B cell development in vitro as well as in vivo, upstream of the EBF-E2A-Pax5 regulatory complex and increased immunoglobulin secretion. These data revealed a bursal-derived multifunctional factor BP8 as a novel biomaterial which is essential for the development of the immune system. This study elucidates further the mechanisms involved in humoral immune system and has implications in treating human diseases.

Original languageEnglish (US)
Pages (from-to)2705-2713
Number of pages9
JournalAmino Acids
Volume46
Issue number12
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Keywords

  • B cell development
  • Bursal peptide (BP8)
  • Immunomodulatory function

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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