Bovine trichomoniasis as a model for development of vaccines against sexually-transmitted disease

Lynette B. Corbeil, Linda Munson, Carlos Campero, Robert Bondurant

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Problem: Human sexually transmitted diseases (STDs) are widespread but effective vaccines are rare. Experimental and commercially available vaccines for bovine trichomoniasis have been well studied. Principles for immune protection of the female genital tract derived from studies of bovine trichomoniasis may be generally applicable to human trichomoniasis and other STDs. Method of study: A bovine model of trichomoniasis has been developed for study of mechanisms of immunoprophylaxis. Results: Both systemic and local immunization with an immunoaffinity purified antigen cleared the genital tract of trichomonads significantly earlier than non-immunized controls. Predominantly IgA responses or poredominantly IgG responses in uterine and vaginal secretions were essentially equally protective. Uterine and vaginal IgA responses could be induced by systemic priming and local boosting via either the vaginal or nasal mucosa. In either case, lymphoid aggregates were formed in the uterine and vaginal mucosa which were not present in the genital mucosa of naïve animals. Conclusions: Systemic immunization or systemic priming with local boosting protects against bovine trichomoniasis via IgG or IgA antibodies (respectively) to a major surface antigen of trichomonads. Immunization of the genital mucosa results in formation of inductive sites for a local IgA response.

Original languageEnglish (US)
Pages (from-to)310-319
Number of pages10
JournalAmerican Journal of Reproductive Immunology
Issue number5
StatePublished - May 2001


  • Common mucosal immune system
  • Genital immunity
  • Vaginal/uterine IgA responses

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynecology


Dive into the research topics of 'Bovine trichomoniasis as a model for development of vaccines against sexually-transmitted disease'. Together they form a unique fingerprint.

Cite this