Abstract
Bovine respiratory syncytial virus (BRSV) causes severe respiratory disease in young cattle. Much like the human respiratory syncytial virus, BRSV induces immunomodulation in the infected host, favoring a Th2 response. Several groups have demonstrated IgE responses to BRSV proteins during infection and particularly in response to vaccination with formalin-inactivated vaccine in the field and experimentally. Newer vaccine modalities that favor a shift to Th1 cytokine production have provided promising results. Infection with BRSV is a major contributor to the multi-pathogen disease, bovine respiratory disease complex. This review stresses the unique immunomodulatory aspects of BRSV infection, vaccination and its interaction with the host's immune system.
Original language | English (US) |
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Pages (from-to) | 207-213 |
Number of pages | 7 |
Journal | Animal health research reviews / Conference of Research Workers in Animal Diseases |
Volume | 8 |
Issue number | 2 |
State | Published - Dec 2007 |
ASJC Scopus subject areas
- Medicine(all)