Bovine abortion caused by Coxiella burnetii: report of a cluster of cases in Uruguay and review of the literature

Melissa Macías-Rioseco, Franklin Riet-Correa, Myrna M. Miller, Kerry Sondgeroth, Martin Fraga, Caroline Silveira, Francisco A Uzal, Federico Giannitti

Research output: Contribution to journalArticle

Abstract

A cluster of 4 bovine abortions caused by Coxiella burnetii occurred in a dairy herd in Uruguay during a 2-mo period. Case 1 consisted of a placenta from an aborted cow; cases 2–4 were fetuses and their placentas. Grossly, the placenta from one aborted cow had moderate, diffuse reddening of the cotyledons and loss of translucency of the intercotyledonary areas. No gross lesions were observed in the other 3 placentas. Microscopically, 2 of 4 placentas had fibrinonecrotizing placentitis with abundant intratrophoblastic gram-negative coccobacilli. C. burnetii was identified intralesionally by immunohistochemistry (IHC) in all 4 placentas, and by PCR and DNA sequencing in 3 placentas analyzed by these techniques. One fetus had mild neutrophilic alveolitis with multinucleate syncytial cells; no gross or microscopic lesions were observed in the other 2 fetuses examined. The lungs of the 3 fetuses were negative for C. burnetii by IHC. Tests performed to investigate other possible causes of abortions in the 4 cases were negative. C. burnetii causes Q fever in humans and coxiellosis in animals. Clusters of abortions in cattle by C. burnetii have not been reported previously, to our knowledge; this bacterium has been considered an opportunistic pathogen associated only with sporadic abortion in cattle. We present herein a cluster of 4 bovine abortions caused by C. burnetii in a dairy farm during a period of 2 mo and a review of the literature on C. burnetii infection in cattle.

Original languageEnglish (US)
Pages (from-to)634-639
Number of pages6
JournalJournal of Veterinary Diagnostic Investigation
Volume31
Issue number4
DOIs
StatePublished - Jul 1 2019

Fingerprint

Uruguay
Coxiella burnetii
abortion (animals)
placenta
Placenta
cattle
fetus
Fetus
Q fever
Q Fever
lesions (animal)
immunohistochemistry
Immunohistochemistry
alveolitis
cows
Cotyledon
DNA Sequence Analysis
dairy herds
dairy farming
cotyledons

Keywords

  • bovine abortion
  • Coxiella burnetii
  • coxiellosis
  • Q fever
  • zoonosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Macías-Rioseco, M., Riet-Correa, F., Miller, M. M., Sondgeroth, K., Fraga, M., Silveira, C., ... Giannitti, F. (2019). Bovine abortion caused by Coxiella burnetii: report of a cluster of cases in Uruguay and review of the literature. Journal of Veterinary Diagnostic Investigation, 31(4), 634-639. https://doi.org/10.1177/1040638719856394

Bovine abortion caused by Coxiella burnetii : report of a cluster of cases in Uruguay and review of the literature. / Macías-Rioseco, Melissa; Riet-Correa, Franklin; Miller, Myrna M.; Sondgeroth, Kerry; Fraga, Martin; Silveira, Caroline; Uzal, Francisco A; Giannitti, Federico.

In: Journal of Veterinary Diagnostic Investigation, Vol. 31, No. 4, 01.07.2019, p. 634-639.

Research output: Contribution to journalArticle

Macías-Rioseco, M, Riet-Correa, F, Miller, MM, Sondgeroth, K, Fraga, M, Silveira, C, Uzal, FA & Giannitti, F 2019, 'Bovine abortion caused by Coxiella burnetii: report of a cluster of cases in Uruguay and review of the literature', Journal of Veterinary Diagnostic Investigation, vol. 31, no. 4, pp. 634-639. https://doi.org/10.1177/1040638719856394
Macías-Rioseco, Melissa ; Riet-Correa, Franklin ; Miller, Myrna M. ; Sondgeroth, Kerry ; Fraga, Martin ; Silveira, Caroline ; Uzal, Francisco A ; Giannitti, Federico. / Bovine abortion caused by Coxiella burnetii : report of a cluster of cases in Uruguay and review of the literature. In: Journal of Veterinary Diagnostic Investigation. 2019 ; Vol. 31, No. 4. pp. 634-639.
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