Botulinum A toxin (Oculinum®) in ophthalmology

Masahiro Osako, John L Keltner

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


Botulinum A toxin has been used to treat strabismus and a variety of spasmodic neuromuscular diseases. Botulinum toxin treatment of strabismus is not as definitive and stable as the traditional surgical approach, but it has been found most useful in postoperative overcorrection, small deviations, sensory deviations, and acute sixth nerve palsy. This toxin has been effective in the treatment of essential blepharospasm and hemifacial spasm, for which it produces temporary relief of symptoms. In addition, this treatment has been applied to lower lid entropion, myokymia, aberrant regeneration of the seventh nerve, lid retraction, corneal exposure, nystagmus, spasmodic torticollis, and adductor spastic dysphonia.

Original languageEnglish (US)
Pages (from-to)28-46
Number of pages19
JournalSurvey of Ophthalmology
Issue number1
StatePublished - 1991


  • adductor spastic dysphonia
  • botulinum A toxin
  • essential blepharospasm
  • hemifacial spasm
  • lid retraction
  • lower lid entropion
  • motility
  • myokyomia
  • nystagmus
  • spasmodic torticollis

ASJC Scopus subject areas

  • Ophthalmology


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