Botulinum A toxin (Oculinum®) in ophthalmology

Masahiro Osako, John L Keltner

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Botulinum A toxin has been used to treat strabismus and a variety of spasmodic neuromuscular diseases. Botulinum toxin treatment of strabismus is not as definitive and stable as the traditional surgical approach, but it has been found most useful in postoperative overcorrection, small deviations, sensory deviations, and acute sixth nerve palsy. This toxin has been effective in the treatment of essential blepharospasm and hemifacial spasm, for which it produces temporary relief of symptoms. In addition, this treatment has been applied to lower lid entropion, myokymia, aberrant regeneration of the seventh nerve, lid retraction, corneal exposure, nystagmus, spasmodic torticollis, and adductor spastic dysphonia.

Original languageEnglish (US)
Pages (from-to)28-46
Number of pages19
JournalSurvey of Ophthalmology
Volume36
Issue number1
DOIs
StatePublished - 1991

Fingerprint

Type A Botulinum Toxins
Strabismus
Ophthalmology
Myokymia
Entropion
Abducens Nerve Diseases
Hemifacial Spasm
Dysphonia
Torticollis
Neuromuscular Diseases
Nerve Regeneration
Botulinum Toxins
Benign essential blepharospasm

Keywords

  • adductor spastic dysphonia
  • botulinum A toxin
  • essential blepharospasm
  • hemifacial spasm
  • lid retraction
  • lower lid entropion
  • motility
  • myokyomia
  • nystagmus
  • spasmodic torticollis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Botulinum A toxin (Oculinum®) in ophthalmology. / Osako, Masahiro; Keltner, John L.

In: Survey of Ophthalmology, Vol. 36, No. 1, 1991, p. 28-46.

Research output: Contribution to journalReview article

Osako, Masahiro ; Keltner, John L. / Botulinum A toxin (Oculinum®) in ophthalmology. In: Survey of Ophthalmology. 1991 ; Vol. 36, No. 1. pp. 28-46.
@article{9c84a76245b7489db338dda543bece27,
title = "Botulinum A toxin (Oculinum{\circledR}) in ophthalmology",
abstract = "Botulinum A toxin has been used to treat strabismus and a variety of spasmodic neuromuscular diseases. Botulinum toxin treatment of strabismus is not as definitive and stable as the traditional surgical approach, but it has been found most useful in postoperative overcorrection, small deviations, sensory deviations, and acute sixth nerve palsy. This toxin has been effective in the treatment of essential blepharospasm and hemifacial spasm, for which it produces temporary relief of symptoms. In addition, this treatment has been applied to lower lid entropion, myokymia, aberrant regeneration of the seventh nerve, lid retraction, corneal exposure, nystagmus, spasmodic torticollis, and adductor spastic dysphonia.",
keywords = "adductor spastic dysphonia, botulinum A toxin, essential blepharospasm, hemifacial spasm, lid retraction, lower lid entropion, motility, myokyomia, nystagmus, spasmodic torticollis",
author = "Masahiro Osako and Keltner, {John L}",
year = "1991",
doi = "10.1016/0039-6257(91)90207-V",
language = "English (US)",
volume = "36",
pages = "28--46",
journal = "Survey of Ophthalmology",
issn = "0039-6257",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Botulinum A toxin (Oculinum®) in ophthalmology

AU - Osako, Masahiro

AU - Keltner, John L

PY - 1991

Y1 - 1991

N2 - Botulinum A toxin has been used to treat strabismus and a variety of spasmodic neuromuscular diseases. Botulinum toxin treatment of strabismus is not as definitive and stable as the traditional surgical approach, but it has been found most useful in postoperative overcorrection, small deviations, sensory deviations, and acute sixth nerve palsy. This toxin has been effective in the treatment of essential blepharospasm and hemifacial spasm, for which it produces temporary relief of symptoms. In addition, this treatment has been applied to lower lid entropion, myokymia, aberrant regeneration of the seventh nerve, lid retraction, corneal exposure, nystagmus, spasmodic torticollis, and adductor spastic dysphonia.

AB - Botulinum A toxin has been used to treat strabismus and a variety of spasmodic neuromuscular diseases. Botulinum toxin treatment of strabismus is not as definitive and stable as the traditional surgical approach, but it has been found most useful in postoperative overcorrection, small deviations, sensory deviations, and acute sixth nerve palsy. This toxin has been effective in the treatment of essential blepharospasm and hemifacial spasm, for which it produces temporary relief of symptoms. In addition, this treatment has been applied to lower lid entropion, myokymia, aberrant regeneration of the seventh nerve, lid retraction, corneal exposure, nystagmus, spasmodic torticollis, and adductor spastic dysphonia.

KW - adductor spastic dysphonia

KW - botulinum A toxin

KW - essential blepharospasm

KW - hemifacial spasm

KW - lid retraction

KW - lower lid entropion

KW - motility

KW - myokyomia

KW - nystagmus

KW - spasmodic torticollis

UR - http://www.scopus.com/inward/record.url?scp=0025938510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025938510&partnerID=8YFLogxK

U2 - 10.1016/0039-6257(91)90207-V

DO - 10.1016/0039-6257(91)90207-V

M3 - Review article

C2 - 1925943

AN - SCOPUS:0025938510

VL - 36

SP - 28

EP - 46

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

SN - 0039-6257

IS - 1

ER -