Bortezomib-based combinations in the treatment of non-small-cell lung cancer.

Angela M. Davies, Primo N Lara, Philip Mack, Paul H. Gumerlock, Richard J Bold, David R Gandara

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Lung cancer is the most common cause of cancer-related death among men and women in the United States. Current trials are focusing on the integration of novel therapeutic agents into current non-small-cell lung cancer (NSCLC) treatment paradigms. Bortezomib, a small-molecule proteasome inhibitor, has single-agent activity in NSCLC and in combination with agents commonly used in NSCLC. This article will review the rationale and preclinical data supporting bortezomib combinations and the clinical trials with bortezomib alone and in combination in NSCLC to date.

Original languageEnglish (US)
JournalClinical lung cancer.
Volume7 Suppl 2
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Cancer Research
  • Pulmonary and Respiratory Medicine

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