Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis

J. Anguita, M. Rincon, S. Samanta, Stephen W Barthold, R. A. Flavell, E. Fikrig

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Recently, interleukin (IL)-6 was shown to be one of the earliest factors that trigger the differentiation of naive T cells into effector Th2 cells in vitro. Lyme arthritis was studied in IL-6-deficient mice, since joint inflammation is influenced by the T helper cell response against Borrelia burgdorferi. Arthritis incidence increased in B. burgdorferi-infected IL-6- deficient mice compared with that in controls. Furthermore, splenocytes of B. burgdorferi-infected IL-6-deficient mice produced significantly less IL-4 in response to Borrelia antigens than did C57BL/6 (B6) mice, and B. burgdorferi- specific IgG2b levels were significantly reduced in IL-6-deficient mice at 60 days of infection. These results extend previous in vitro observations by demonstrating an in vivo role for IL-6 in the differentiation of CD4 T cells toward a Th2 phenotype and further show that CD4 T cell responses influence murine Lyme arthritis.

Original languageEnglish (US)
Pages (from-to)1512-1515
Number of pages4
JournalJournal of Infectious Diseases
Volume178
Issue number5
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Borrelia burgdorferi
Lyme Disease
T-Lymphocytes
Interleukin-6
Borrelia
Th2 Cells
Helper-Inducer T-Lymphocytes
Interleukin-4
Arthritis
Joints
Inflammation
Phenotype
Antigens
mouse interleukin-6
Incidence
Infection
In Vitro Techniques

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis. / Anguita, J.; Rincon, M.; Samanta, S.; Barthold, Stephen W; Flavell, R. A.; Fikrig, E.

In: Journal of Infectious Diseases, Vol. 178, No. 5, 1998, p. 1512-1515.

Research output: Contribution to journalArticle

Anguita, J. ; Rincon, M. ; Samanta, S. ; Barthold, Stephen W ; Flavell, R. A. ; Fikrig, E. / Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis. In: Journal of Infectious Diseases. 1998 ; Vol. 178, No. 5. pp. 1512-1515.
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