Border disease in a flock of sheep: epidemiologic, laboratory, and clinical findings.

M. M. Sawyer, C. E. Schore, P. I. Menzies, Bennie Osburn

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A flock of sheep in which border disease (BD) was enzootic was studied through a breeding season. At the beginning of the study (August 1981), 125 (82%) of 152 ewes were seropositive to the cross-reacting bovine viral diarrhea virus. Within 7 months, 3 (18%) of 17 seropositive ewes retested had reverted to seronegative. Of the remaining 21 ewes identified as seronegative, 7 (33%) converted to seropositive by the end of the study. Triplet lambs were born, 2 of which exhibited clinical signs of BD. The virus was isolated from blood lymphocytes from both of the affected lambs. The most severely affected lamb shed virus into the urine, saliva, and feces through 10 weeks of age. Lymphocyte stimulation tests indicated that the lymphocytes from the affected lambs had decreased function in months 4 through 7, but returned to normal function by the eighth month. Transmission of BD virus was investigated by exposing 5 seronegative ewes to the BD-infected lambs. Two of the contact ewes developed viremia and 3 converted to seropositive within the 13-week exposure period. Evidence from this and other studies supports a model of BD in gravid, nongravid, and persistently infected adult sheep.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume189
Issue number1
StatePublished - Jul 1 1986
Externally publishedYes

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Border Disease
border disease
ewes
Sheep
flocks
lambs
sheep
Border disease virus
Lymphocytes
Viruses
Bovine Viral Diarrhea Viruses
lymphocytes
Viremia
Lymphocyte Activation
viruses
Saliva
Feces
viremia
sheds
Breeding

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Border disease in a flock of sheep : epidemiologic, laboratory, and clinical findings. / Sawyer, M. M.; Schore, C. E.; Menzies, P. I.; Osburn, Bennie.

In: Journal of the American Veterinary Medical Association, Vol. 189, No. 1, 01.07.1986, p. 61-65.

Research output: Contribution to journalArticle

Sawyer, M. M. ; Schore, C. E. ; Menzies, P. I. ; Osburn, Bennie. / Border disease in a flock of sheep : epidemiologic, laboratory, and clinical findings. In: Journal of the American Veterinary Medical Association. 1986 ; Vol. 189, No. 1. pp. 61-65.
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