Abstract
Purpose: The majority of breast cancer patients receive endocrine therapy, including aromatase inhibitors known to cause increased bone resorption. Bone-related biomarkers at the time of breast cancer diagnosis may predict future risk of osteoporosis and fracture after endocrine therapy. Methods: In a large population of 2,401 female breast cancer patients who later underwent endocrine therapy, we measured two bone remodeling biomarkers, TRAP5b and BAP, and two bone regulating biomarkers, RANKL and OPG, in serum samples collected at the time of breast cancer diagnosis. We analyzed these biomarkers and their ratios with patients’ demographic, lifestyle, clinical tumor characteristics, as well as bone health history. Results: The presence of bone metastases, prior bisphosphonate (BP) treatment, and blood collection after chemotherapy had a significant impact on biomarker levels. After excluding these cases and controlling for blood collection time, several factors, including age, race/ethnicity, body mass index, physical activity, alcohol consumption, smoking, and hormonal replacement therapy, were significantly associated with bone biomarkers, while vitamin D or calcium supplements and tumor characteristics were not. When prior BP users were included in, recent history of osteoporosis and fracture was also associated. Conclusions: Our findings support further investigation of these biomarkers with bone health outcomes after endocrine therapy initiation in women with breast cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-13 |
| Number of pages | 13 |
| Journal | Breast Cancer Research and Treatment |
| DOIs | |
| State | Accepted/In press - Dec 3 2016 |
| Externally published | Yes |
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Keywords
- Aromatase inhibitor
- Biomarker
- Bone
- Breast cancer
- Tamoxifen
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis. / Yao, Song; Zhang, Yali; Tang, Li; Roh, Janise M.; Laurent, Cecile A.; Hong, Chi Chen; Hahn, Theresa; Lo, Joan C.; Ambrosone, Christine B.; Kushi, Lawrence H.; Kwan, Marilyn L.
In: Breast Cancer Research and Treatment, 03.12.2016, p. 1-13.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis
AU - Yao, Song
AU - Zhang, Yali
AU - Tang, Li
AU - Roh, Janise M.
AU - Laurent, Cecile A.
AU - Hong, Chi Chen
AU - Hahn, Theresa
AU - Lo, Joan C.
AU - Ambrosone, Christine B.
AU - Kushi, Lawrence H.
AU - Kwan, Marilyn L.
PY - 2016/12/3
Y1 - 2016/12/3
N2 - Purpose: The majority of breast cancer patients receive endocrine therapy, including aromatase inhibitors known to cause increased bone resorption. Bone-related biomarkers at the time of breast cancer diagnosis may predict future risk of osteoporosis and fracture after endocrine therapy. Methods: In a large population of 2,401 female breast cancer patients who later underwent endocrine therapy, we measured two bone remodeling biomarkers, TRAP5b and BAP, and two bone regulating biomarkers, RANKL and OPG, in serum samples collected at the time of breast cancer diagnosis. We analyzed these biomarkers and their ratios with patients’ demographic, lifestyle, clinical tumor characteristics, as well as bone health history. Results: The presence of bone metastases, prior bisphosphonate (BP) treatment, and blood collection after chemotherapy had a significant impact on biomarker levels. After excluding these cases and controlling for blood collection time, several factors, including age, race/ethnicity, body mass index, physical activity, alcohol consumption, smoking, and hormonal replacement therapy, were significantly associated with bone biomarkers, while vitamin D or calcium supplements and tumor characteristics were not. When prior BP users were included in, recent history of osteoporosis and fracture was also associated. Conclusions: Our findings support further investigation of these biomarkers with bone health outcomes after endocrine therapy initiation in women with breast cancer.
AB - Purpose: The majority of breast cancer patients receive endocrine therapy, including aromatase inhibitors known to cause increased bone resorption. Bone-related biomarkers at the time of breast cancer diagnosis may predict future risk of osteoporosis and fracture after endocrine therapy. Methods: In a large population of 2,401 female breast cancer patients who later underwent endocrine therapy, we measured two bone remodeling biomarkers, TRAP5b and BAP, and two bone regulating biomarkers, RANKL and OPG, in serum samples collected at the time of breast cancer diagnosis. We analyzed these biomarkers and their ratios with patients’ demographic, lifestyle, clinical tumor characteristics, as well as bone health history. Results: The presence of bone metastases, prior bisphosphonate (BP) treatment, and blood collection after chemotherapy had a significant impact on biomarker levels. After excluding these cases and controlling for blood collection time, several factors, including age, race/ethnicity, body mass index, physical activity, alcohol consumption, smoking, and hormonal replacement therapy, were significantly associated with bone biomarkers, while vitamin D or calcium supplements and tumor characteristics were not. When prior BP users were included in, recent history of osteoporosis and fracture was also associated. Conclusions: Our findings support further investigation of these biomarkers with bone health outcomes after endocrine therapy initiation in women with breast cancer.
KW - Aromatase inhibitor
KW - Biomarker
KW - Bone
KW - Breast cancer
KW - Tamoxifen
UR - http://www.scopus.com/inward/record.url?scp=85002959406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85002959406&partnerID=8YFLogxK
U2 - 10.1007/s10549-016-4068-5
DO - 10.1007/s10549-016-4068-5
M3 - Article
SP - 1
EP - 13
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
ER -