Abstract
It is conventional to identify morphogens from fly and frog embryos during morphogenesis using genescreens, substractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokines isolated and cloned from the demineralized extracellular matrix of adult bone. Thus, BMPs were isolated from mammalian bone by an unconventional approach. BMPs initiate the sequential developmental cascade of bone morphogenesis in ectopic sites. The pleiotropic effects of BMPs on chemotaxis, mitosis and differentiation are based on concentration-dependent thresholds. Recent work has demonstrated the critical role of BMPs in pattern formation in amphibian and chick limb development. Targeted disruption of gene function by homologous recombination has demonstrated the actions of BMPs beyond bone in such disparate tissues as kidney, eye, testis, teeth, skin and heart. The successful isolation of first mammalian morphogens has laid the foundation for the elucidation of molecular signalling during morphogenesis in bones and beyond.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-20 |
| Number of pages | 10 |
| Journal | Cytokine and Growth Factor Reviews |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1997 |
| Externally published | Yes |
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Keywords
- Cartilage
- Chemotaxis
- Norphogenesis
- Pleiotropy
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Bone morphogenetic proteins : An unconventional approach to isolation of first mammalian morphogens. / Reddi, A Hari.
In: Cytokine and Growth Factor Reviews, Vol. 8, No. 1, 03.1997, p. 11-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone morphogenetic proteins
T2 - An unconventional approach to isolation of first mammalian morphogens
AU - Reddi, A Hari
PY - 1997/3
Y1 - 1997/3
N2 - It is conventional to identify morphogens from fly and frog embryos during morphogenesis using genescreens, substractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokines isolated and cloned from the demineralized extracellular matrix of adult bone. Thus, BMPs were isolated from mammalian bone by an unconventional approach. BMPs initiate the sequential developmental cascade of bone morphogenesis in ectopic sites. The pleiotropic effects of BMPs on chemotaxis, mitosis and differentiation are based on concentration-dependent thresholds. Recent work has demonstrated the critical role of BMPs in pattern formation in amphibian and chick limb development. Targeted disruption of gene function by homologous recombination has demonstrated the actions of BMPs beyond bone in such disparate tissues as kidney, eye, testis, teeth, skin and heart. The successful isolation of first mammalian morphogens has laid the foundation for the elucidation of molecular signalling during morphogenesis in bones and beyond.
AB - It is conventional to identify morphogens from fly and frog embryos during morphogenesis using genescreens, substractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokines isolated and cloned from the demineralized extracellular matrix of adult bone. Thus, BMPs were isolated from mammalian bone by an unconventional approach. BMPs initiate the sequential developmental cascade of bone morphogenesis in ectopic sites. The pleiotropic effects of BMPs on chemotaxis, mitosis and differentiation are based on concentration-dependent thresholds. Recent work has demonstrated the critical role of BMPs in pattern formation in amphibian and chick limb development. Targeted disruption of gene function by homologous recombination has demonstrated the actions of BMPs beyond bone in such disparate tissues as kidney, eye, testis, teeth, skin and heart. The successful isolation of first mammalian morphogens has laid the foundation for the elucidation of molecular signalling during morphogenesis in bones and beyond.
KW - Cartilage
KW - Chemotaxis
KW - Norphogenesis
KW - Pleiotropy
UR - http://www.scopus.com/inward/record.url?scp=0031105160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031105160&partnerID=8YFLogxK
U2 - 10.1016/S1359-6101(96)00049-4
DO - 10.1016/S1359-6101(96)00049-4
M3 - Article
C2 - 9174660
AN - SCOPUS:0031105160
VL - 8
SP - 11
EP - 20
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
SN - 1359-6101
IS - 1
ER -