Bone morphogenetic protein: Chromosomal localization of human genes for BMP1, BMP2A, and BMP3

Jeffrey A. Tabas, Michael Zasloff, John J. Wasmuth, Beverly S. Emanuel, Michael R. Altherr, John Douglas Mcpherson, John M. Wozney, Frederick S. Kaplan

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Bone morphogenetic protein (BMP) induces endochondral bone formation in vivo. The human genes have been cloned for a group of proteins containing BMP activity (BMP1, BMP2A, and BMP3). Two of the proteins are members of the transforming growth factor-β supergene family (BMP2A and BMP3), while BMP1 is a novel regulatory protein. Using somatic cell hybrid lines, cDNA probes were used to map BMP1 to chromosome 8, BMP2A to chromosome 20, and BMP3 to the p14-q21 region of chromosome 4. This analysis reveals that the BMP2A and BMP3 genes map to conserved regions between mouse and human, while the BMP1 gene does not. The locations of the BMP genes were found to overlap with the loci for several disorders of cartilage and bone formation.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalGenomics
Volume9
Issue number2
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Genetics

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    Tabas, J. A., Zasloff, M., Wasmuth, J. J., Emanuel, B. S., Altherr, M. R., Mcpherson, J. D., Wozney, J. M., & Kaplan, F. S. (1991). Bone morphogenetic protein: Chromosomal localization of human genes for BMP1, BMP2A, and BMP3. Genomics, 9(2), 283-289. https://doi.org/10.1016/0888-7543(91)90254-C