Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group

R. K. Chaganti, N. Parimi, T. Lang, E. Orwoll, M. L. Stefanick, M. Nevitt, Nancy E Lane

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We evaluated the association of bone mineral density (BMD) and osteoarthritis (OA) of the hip in elderly men. We found that elderly men with moderate to severe radiographic hip OA (RHOA) had significantly higher areal BMD (aBMD) and volumetric BMD (vBMD) at both the lumbar spine and hip compared to age similar controls without OA. Introduction: We evaluated the association of BMD measured by dual energy X-ray absorptiometry (DXA) and quantitative computerized tomography (integral, cortical, and trabecular vBMD) and RHOA in a cohort of elderly men. Methods: A cross-sectional analysis was conducted within the Study of Osteoporotic Fractures in Men, a prospective cohort study of 5,995 US men age≥65 years. Standing pelvic x-rays were done in 4,024 subjects and scored for prevalent RHOA severity. DXA was done in 3,886 subjects, and aBMD and vBMD associations were compared with RHOA score using linear regression, adjusting for covariates. Results: Both moderate and severe RHOA groups had significantly higher aBMD at all BMD sites (range, 3.7-10.0% difference; p value 0.0012 and p value<0.005) compared to the control group with no RHOA. The difference remained strong after adjusting for covariates. While the total hip and lumbar spine cortical vBMD measurements of subjects with moderate or severe RHOA was increased compared to controls, trabecular vBMD was not. Conclusion: Older men, with both moderate and severe RHOA, had significantly higher aBMD and integral vBMD at the hip and lumbar spine compared to controls without RHOA.

Original languageEnglish (US)
Pages (from-to)1307-1316
Number of pages10
JournalOsteoporosis International
Volume21
Issue number8
DOIs
StatePublished - Aug 2010

Fingerprint

Hip Osteoarthritis
Osteoporotic Fractures
Bone Density
Hip
Spine
Photon Absorptiometry
Osteoarthritis
Linear Models
Cohort Studies
Cross-Sectional Studies
Tomography
X-Rays
Prospective Studies

Keywords

  • Hip osteoarthritis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group. / Chaganti, R. K.; Parimi, N.; Lang, T.; Orwoll, E.; Stefanick, M. L.; Nevitt, M.; Lane, Nancy E.

In: Osteoporosis International, Vol. 21, No. 8, 08.2010, p. 1307-1316.

Research output: Contribution to journalArticle

Chaganti, R. K. ; Parimi, N. ; Lang, T. ; Orwoll, E. ; Stefanick, M. L. ; Nevitt, M. ; Lane, Nancy E. / Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group. In: Osteoporosis International. 2010 ; Vol. 21, No. 8. pp. 1307-1316.
@article{498cb4c3737f4a70b559306d54017615,
title = "Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group",
abstract = "We evaluated the association of bone mineral density (BMD) and osteoarthritis (OA) of the hip in elderly men. We found that elderly men with moderate to severe radiographic hip OA (RHOA) had significantly higher areal BMD (aBMD) and volumetric BMD (vBMD) at both the lumbar spine and hip compared to age similar controls without OA. Introduction: We evaluated the association of BMD measured by dual energy X-ray absorptiometry (DXA) and quantitative computerized tomography (integral, cortical, and trabecular vBMD) and RHOA in a cohort of elderly men. Methods: A cross-sectional analysis was conducted within the Study of Osteoporotic Fractures in Men, a prospective cohort study of 5,995 US men age≥65 years. Standing pelvic x-rays were done in 4,024 subjects and scored for prevalent RHOA severity. DXA was done in 3,886 subjects, and aBMD and vBMD associations were compared with RHOA score using linear regression, adjusting for covariates. Results: Both moderate and severe RHOA groups had significantly higher aBMD at all BMD sites (range, 3.7-10.0{\%} difference; p value 0.0012 and p value<0.005) compared to the control group with no RHOA. The difference remained strong after adjusting for covariates. While the total hip and lumbar spine cortical vBMD measurements of subjects with moderate or severe RHOA was increased compared to controls, trabecular vBMD was not. Conclusion: Older men, with both moderate and severe RHOA, had significantly higher aBMD and integral vBMD at the hip and lumbar spine compared to controls without RHOA.",
keywords = "Hip osteoarthritis",
author = "Chaganti, {R. K.} and N. Parimi and T. Lang and E. Orwoll and Stefanick, {M. L.} and M. Nevitt and Lane, {Nancy E}",
year = "2010",
month = "8",
doi = "10.1007/s00198-009-1105-9",
language = "English (US)",
volume = "21",
pages = "1307--1316",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "8",

}

TY - JOUR

T1 - Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group

AU - Chaganti, R. K.

AU - Parimi, N.

AU - Lang, T.

AU - Orwoll, E.

AU - Stefanick, M. L.

AU - Nevitt, M.

AU - Lane, Nancy E

PY - 2010/8

Y1 - 2010/8

N2 - We evaluated the association of bone mineral density (BMD) and osteoarthritis (OA) of the hip in elderly men. We found that elderly men with moderate to severe radiographic hip OA (RHOA) had significantly higher areal BMD (aBMD) and volumetric BMD (vBMD) at both the lumbar spine and hip compared to age similar controls without OA. Introduction: We evaluated the association of BMD measured by dual energy X-ray absorptiometry (DXA) and quantitative computerized tomography (integral, cortical, and trabecular vBMD) and RHOA in a cohort of elderly men. Methods: A cross-sectional analysis was conducted within the Study of Osteoporotic Fractures in Men, a prospective cohort study of 5,995 US men age≥65 years. Standing pelvic x-rays were done in 4,024 subjects and scored for prevalent RHOA severity. DXA was done in 3,886 subjects, and aBMD and vBMD associations were compared with RHOA score using linear regression, adjusting for covariates. Results: Both moderate and severe RHOA groups had significantly higher aBMD at all BMD sites (range, 3.7-10.0% difference; p value 0.0012 and p value<0.005) compared to the control group with no RHOA. The difference remained strong after adjusting for covariates. While the total hip and lumbar spine cortical vBMD measurements of subjects with moderate or severe RHOA was increased compared to controls, trabecular vBMD was not. Conclusion: Older men, with both moderate and severe RHOA, had significantly higher aBMD and integral vBMD at the hip and lumbar spine compared to controls without RHOA.

AB - We evaluated the association of bone mineral density (BMD) and osteoarthritis (OA) of the hip in elderly men. We found that elderly men with moderate to severe radiographic hip OA (RHOA) had significantly higher areal BMD (aBMD) and volumetric BMD (vBMD) at both the lumbar spine and hip compared to age similar controls without OA. Introduction: We evaluated the association of BMD measured by dual energy X-ray absorptiometry (DXA) and quantitative computerized tomography (integral, cortical, and trabecular vBMD) and RHOA in a cohort of elderly men. Methods: A cross-sectional analysis was conducted within the Study of Osteoporotic Fractures in Men, a prospective cohort study of 5,995 US men age≥65 years. Standing pelvic x-rays were done in 4,024 subjects and scored for prevalent RHOA severity. DXA was done in 3,886 subjects, and aBMD and vBMD associations were compared with RHOA score using linear regression, adjusting for covariates. Results: Both moderate and severe RHOA groups had significantly higher aBMD at all BMD sites (range, 3.7-10.0% difference; p value 0.0012 and p value<0.005) compared to the control group with no RHOA. The difference remained strong after adjusting for covariates. While the total hip and lumbar spine cortical vBMD measurements of subjects with moderate or severe RHOA was increased compared to controls, trabecular vBMD was not. Conclusion: Older men, with both moderate and severe RHOA, had significantly higher aBMD and integral vBMD at the hip and lumbar spine compared to controls without RHOA.

KW - Hip osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=77954541261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954541261&partnerID=8YFLogxK

U2 - 10.1007/s00198-009-1105-9

DO - 10.1007/s00198-009-1105-9

M3 - Article

C2 - 20101493

AN - SCOPUS:77954541261

VL - 21

SP - 1307

EP - 1316

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 8

ER -