Bone marrow transplantation for canine X-linked severe combined immunodeficiency

Brian J. Hartnett, Paula S. Henthorn, Peter F Moore, Kenneth I. Weinberg, Hans D. Ochs, Peter J. Felsburg

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the common γ chain which is a subunit of the receptors of IL-2, IL-4, IL-7, IL-9 and IL-15. Bone marrow transplantation (BMT) of human XSCID patients without pretransplant conditioning (cytoablation) results in engraftment of donor T-cells and reconstitution of T-cell function but engraftment of few, if any, donor B cells with resultant poor reconstitution of humoral immune function. In this study, we show that XSCID dogs can be transplanted with allogeneic bone marrow cells resulting in engraftment of both donor B and T cells and reconstitution of full systemic immune function including normal humoral immune function without the need for cytoablation.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume69
Issue number2-4
DOIs
StatePublished - Aug 2 1999

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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