Bone marrow transplantation for canine X-linked severe combined immunodeficiency

Brian J. Hartnett, Paula S. Henthorn, Peter F Moore, Kenneth I. Weinberg, Hans D. Ochs, Peter J. Felsburg

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the common γ chain which is a subunit of the receptors of IL-2, IL-4, IL-7, IL-9 and IL-15. Bone marrow transplantation (BMT) of human XSCID patients without pretransplant conditioning (cytoablation) results in engraftment of donor T-cells and reconstitution of T-cell function but engraftment of few, if any, donor B cells with resultant poor reconstitution of humoral immune function. In this study, we show that XSCID dogs can be transplanted with allogeneic bone marrow cells resulting in engraftment of both donor B and T cells and reconstitution of full systemic immune function including normal humoral immune function without the need for cytoablation.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume69
Issue number2-4
DOIs
StatePublished - Aug 2 1999

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X-Linked Combined Immunodeficiency Diseases
severe combined immunodeficiency
bone marrow transplant
Bone Marrow Transplantation
Canidae
T-lymphocytes
Tissue Donors
T-Lymphocytes
B-lymphocytes
dogs
interleukin-9
B-Lymphocytes
Interleukin-9
interleukin-7
Interleukin-15
Interleukin-7
Interleukin-2 Receptors
bone marrow cells
interleukin-4
interleukin-2

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Bone marrow transplantation for canine X-linked severe combined immunodeficiency. / Hartnett, Brian J.; Henthorn, Paula S.; Moore, Peter F; Weinberg, Kenneth I.; Ochs, Hans D.; Felsburg, Peter J.

In: Veterinary Immunology and Immunopathology, Vol. 69, No. 2-4, 02.08.1999, p. 137-144.

Research output: Contribution to journalArticle

Hartnett, Brian J. ; Henthorn, Paula S. ; Moore, Peter F ; Weinberg, Kenneth I. ; Ochs, Hans D. ; Felsburg, Peter J. / Bone marrow transplantation for canine X-linked severe combined immunodeficiency. In: Veterinary Immunology and Immunopathology. 1999 ; Vol. 69, No. 2-4. pp. 137-144.
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