Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells

Yasuyoshi Sohara, Hiroyuki Shimada, Cedric Minkin, Anat Erdreich-Epstein, Jan Nolta, Yves A. DeClerck

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The bone is the third most common site of cancer metastasis. To invade the bone, tumor cells produce osteoclast-activating factors that increase bone resorption by osteoclasts. Here we report that human neuroblastoma cells that form osteolytic lesions in vivo do not produce osteoclast-activating factors but rather stimulate osteoclast activity in the presence of human bone marrow mesenchymal stem cells. This alternative pathway of osteoclast activation involves a nonadhesive interaction between neuroblastoma cells and bone marrow mesenchymal stem cells. Stimulated bone marrow mesenchymal stem cells express markedly increased levels of interleukin-6, which is then responsible for osteoclast activation. This report describes a critical role of bone marrow mesenchymal stem cells in bone destruction in cancer.

Original languageEnglish (US)
Pages (from-to)1129-1135
Number of pages7
JournalCancer Research
Volume65
Issue number4
DOIs
StatePublished - Feb 15 2005
Externally publishedYes

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Bone Neoplasms
Osteoclasts
Mesenchymal Stromal Cells
Bone Marrow
Neuroblastoma
Bone and Bones
Neoplasms
Bone Resorption
Bone Marrow Cells
Interleukin-6
Neoplasm Metastasis
osteoclast activating factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells. / Sohara, Yasuyoshi; Shimada, Hiroyuki; Minkin, Cedric; Erdreich-Epstein, Anat; Nolta, Jan; DeClerck, Yves A.

In: Cancer Research, Vol. 65, No. 4, 15.02.2005, p. 1129-1135.

Research output: Contribution to journalArticle

Sohara, Yasuyoshi ; Shimada, Hiroyuki ; Minkin, Cedric ; Erdreich-Epstein, Anat ; Nolta, Jan ; DeClerck, Yves A. / Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells. In: Cancer Research. 2005 ; Vol. 65, No. 4. pp. 1129-1135.
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