Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells

Yasuyoshi Sohara, Hiroyuki Shimada, Cedric Minkin, Anat Erdreich-Epstein, Jan Nolta, Yves A. DeClerck

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

The bone is the third most common site of cancer metastasis. To invade the bone, tumor cells produce osteoclast-activating factors that increase bone resorption by osteoclasts. Here we report that human neuroblastoma cells that form osteolytic lesions in vivo do not produce osteoclast-activating factors but rather stimulate osteoclast activity in the presence of human bone marrow mesenchymal stem cells. This alternative pathway of osteoclast activation involves a nonadhesive interaction between neuroblastoma cells and bone marrow mesenchymal stem cells. Stimulated bone marrow mesenchymal stem cells express markedly increased levels of interleukin-6, which is then responsible for osteoclast activation. This report describes a critical role of bone marrow mesenchymal stem cells in bone destruction in cancer.

Original languageEnglish (US)
Pages (from-to)1129-1135
Number of pages7
JournalCancer Research
Volume65
Issue number4
DOIs
StatePublished - Feb 15 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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