Bone marrow changes related to disuse

Lorenzo Nardo, David N. Sandman, Warapat Virayavanich, Linlin Zhang, Richard B. Souza, Lynne Steinbach, Michele Guindani, Thomas M. Link

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. Methods: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20-53 years) at baseline and 5-10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20-50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman's rank correlation test (SRC) and Kendall's tau (KT) were used to compare individual scores. Results: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10-25 weeks (P <0.001). These findings decreased within 1 year (P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). Conclusions: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10-25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present. Key Points: • Disuse is associated with hyperintense MRI signal alteration on fluid-sensitive sequence. • Disuse findings are more prominent at the patella and femoral epiphyses. • Disuse MRI findings appear to be characterised by a specific chronological pattern.

Original languageEnglish (US)
Pages (from-to)3422-3431
Number of pages10
JournalEuropean Radiology
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Bone Marrow
Magnetic Resonance Imaging
Immobilization
Knee
Hyaline Cartilage
Epiphyses
Patella
Knee Joint
Thigh
Volunteers
Lower Extremity

Keywords

  • Bone marrow
  • Disuse
  • Findings
  • Knee
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Nardo, L., Sandman, D. N., Virayavanich, W., Zhang, L., Souza, R. B., Steinbach, L., ... Link, T. M. (2013). Bone marrow changes related to disuse. European Radiology, 23(12), 3422-3431. https://doi.org/10.1007/s00330-013-2943-6

Bone marrow changes related to disuse. / Nardo, Lorenzo; Sandman, David N.; Virayavanich, Warapat; Zhang, Linlin; Souza, Richard B.; Steinbach, Lynne; Guindani, Michele; Link, Thomas M.

In: European Radiology, Vol. 23, No. 12, 01.12.2013, p. 3422-3431.

Research output: Contribution to journalArticle

Nardo, L, Sandman, DN, Virayavanich, W, Zhang, L, Souza, RB, Steinbach, L, Guindani, M & Link, TM 2013, 'Bone marrow changes related to disuse', European Radiology, vol. 23, no. 12, pp. 3422-3431. https://doi.org/10.1007/s00330-013-2943-6
Nardo L, Sandman DN, Virayavanich W, Zhang L, Souza RB, Steinbach L et al. Bone marrow changes related to disuse. European Radiology. 2013 Dec 1;23(12):3422-3431. https://doi.org/10.1007/s00330-013-2943-6
Nardo, Lorenzo ; Sandman, David N. ; Virayavanich, Warapat ; Zhang, Linlin ; Souza, Richard B. ; Steinbach, Lynne ; Guindani, Michele ; Link, Thomas M. / Bone marrow changes related to disuse. In: European Radiology. 2013 ; Vol. 23, No. 12. pp. 3422-3431.
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abstract = "Objectives: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. Methods: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20-53 years) at baseline and 5-10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20-50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman's rank correlation test (SRC) and Kendall's tau (KT) were used to compare individual scores. Results: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10-25 weeks (P <0.001). These findings decreased within 1 year (P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). Conclusions: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10-25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present. Key Points: • Disuse is associated with hyperintense MRI signal alteration on fluid-sensitive sequence. • Disuse findings are more prominent at the patella and femoral epiphyses. • Disuse MRI findings appear to be characterised by a specific chronological pattern.",
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