Abstract
Objectives: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. Methods: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20-53 years) at baseline and 5-10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20-50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman's rank correlation test (SRC) and Kendall's tau (KT) were used to compare individual scores. Results: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10-25 weeks (P <0.001). These findings decreased within 1 year (P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). Conclusions: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10-25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present. Key Points: • Disuse is associated with hyperintense MRI signal alteration on fluid-sensitive sequence. • Disuse findings are more prominent at the patella and femoral epiphyses. • Disuse MRI findings appear to be characterised by a specific chronological pattern.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3422-3431 |
| Number of pages | 10 |
| Journal | European Radiology |
| Volume | 23 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2013 |
| Externally published | Yes |
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Keywords
- Bone marrow
- Disuse
- Findings
- Knee
- Magnetic resonance imaging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Bone marrow changes related to disuse. / Nardo, Lorenzo; Sandman, David N.; Virayavanich, Warapat; Zhang, Linlin; Souza, Richard B.; Steinbach, Lynne; Guindani, Michele; Link, Thomas M.
In: European Radiology, Vol. 23, No. 12, 01.12.2013, p. 3422-3431.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone marrow changes related to disuse
AU - Nardo, Lorenzo
AU - Sandman, David N.
AU - Virayavanich, Warapat
AU - Zhang, Linlin
AU - Souza, Richard B.
AU - Steinbach, Lynne
AU - Guindani, Michele
AU - Link, Thomas M.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Objectives: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. Methods: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20-53 years) at baseline and 5-10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20-50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman's rank correlation test (SRC) and Kendall's tau (KT) were used to compare individual scores. Results: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10-25 weeks (P <0.001). These findings decreased within 1 year (P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). Conclusions: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10-25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present. Key Points: • Disuse is associated with hyperintense MRI signal alteration on fluid-sensitive sequence. • Disuse findings are more prominent at the patella and femoral epiphyses. • Disuse MRI findings appear to be characterised by a specific chronological pattern.
AB - Objectives: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. Methods: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20-53 years) at baseline and 5-10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20-50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman's rank correlation test (SRC) and Kendall's tau (KT) were used to compare individual scores. Results: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10-25 weeks (P <0.001). These findings decreased within 1 year (P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). Conclusions: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10-25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present. Key Points: • Disuse is associated with hyperintense MRI signal alteration on fluid-sensitive sequence. • Disuse findings are more prominent at the patella and femoral epiphyses. • Disuse MRI findings appear to be characterised by a specific chronological pattern.
KW - Bone marrow
KW - Disuse
KW - Findings
KW - Knee
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=84890570756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890570756&partnerID=8YFLogxK
U2 - 10.1007/s00330-013-2943-6
DO - 10.1007/s00330-013-2943-6
M3 - Article
VL - 23
SP - 3422
EP - 3431
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 12
ER -