Bone marrow changes related to disuse

Lorenzo Nardo, David N. Sandman, Warapat Virayavanich, Linlin Zhang, Richard B. Souza, Lynne Steinbach, Michele Guindani, Thomas M. Link

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objectives: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. Methods: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20-53 years) at baseline and 5-10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20-50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman's rank correlation test (SRC) and Kendall's tau (KT) were used to compare individual scores. Results: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10-25 weeks (P <0.001). These findings decreased within 1 year (P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). Conclusions: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10-25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present. Key Points: • Disuse is associated with hyperintense MRI signal alteration on fluid-sensitive sequence. • Disuse findings are more prominent at the patella and femoral epiphyses. • Disuse MRI findings appear to be characterised by a specific chronological pattern.

Original languageEnglish (US)
Pages (from-to)3422-3431
Number of pages10
JournalEuropean Radiology
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Keywords

  • Bone marrow
  • Disuse
  • Findings
  • Knee
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Nardo, L., Sandman, D. N., Virayavanich, W., Zhang, L., Souza, R. B., Steinbach, L., Guindani, M., & Link, T. M. (2013). Bone marrow changes related to disuse. European Radiology, 23(12), 3422-3431. https://doi.org/10.1007/s00330-013-2943-6