Bone induction achieved by controlled release of BMP from PLA/hydroxyapatite foams

S. Kadiyala, H. Lo, M. S. Ponticiello, A Hari Reddi, K. W. Leong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In order to attain bone repair using bone morphogenic proteins (BMP), there is a need for a carrier which can effectively deliver the BMP to the repair site in a controlled fashion and at the same time provide a scaffold for the regenerating tissue to grow upon. The feasibility of using BMP loaded polylactic acid (PLA)/hydroxyapatite (HA) foam fabricated by a novel phase separation technique to induce osteogenesis in an ectopic site in a rat model is demonstrated. Results show that controlled release of BMP from highly porous foams fabricated by the phase separation technique is achieved. Furthermore implantation of these BMP loaded foams in vivo resulted in the ectopic induction of bone and cartilage.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Pages289
Number of pages1
Volume1
Publication statusPublished - 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Kadiyala, S., Lo, H., Ponticiello, M. S., Reddi, A. H., & Leong, K. W. (1996). Bone induction achieved by controlled release of BMP from PLA/hydroxyapatite foams. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1, pp. 289). St. Louis Park, MN, United States: Soc for Biomaterials.