Bone Health and Associated Metabolic Complications in Neuromuscular Diseases

Nanette Joyce, Lauren P. Hache, Paula R. Clemens

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


This article reviews the recent literature regarding bone health as it relates to the patient living with neuromuscular disease (NMD). Studies defining the scope of bone-related disease in NMD are scant. The available evidence is discussed, focusing on abnormal calcium metabolism, increased fracture risk, and the prevalence of both scoliosis and hypovitaminosis D in Duchenne muscular dystrophy, amyotrophic lateral sclerosis, and spinal muscular atrophy. Future directions are discussed, including the urgent need for studies both to determine the nature and extent of poor bone health, and to evaluate the therapeutic effect of available osteoporosis treatments in patients with NMD.

Original languageEnglish (US)
Pages (from-to)773-799
Number of pages27
JournalPhysical Medicine and Rehabilitation Clinics of North America
Issue number4
StatePublished - Nov 2012


  • Bone density
  • Glucocorticoids
  • Neuromuscular disease
  • Scoliosis
  • Vitamin D

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation


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