TY - CHAP
T1 - Bone Cell Mechanoresponsiveness
AU - Genetos, Damian C.
AU - Jacobs, Christopher R.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Improvements in health and nutrition have increased human longevity over the past centuries. Beneficial increases in lifespan, however, are met with novel degenerative and age-related diseases, including atherosclerosis and heart disease, sarcopenia, diabetes, and osteoporosis. The effects of aging upon the skeleton include anatomically heterogeneous involution, alterations in the composition of both the organic and mineral component of the matrix, and accumulation of microdamage. It has been suggested that the process of mechanotransduction within bone is also affected by aging. Within this chapter, we review the process of mechanotransduction in osteogenic cells, highlight those works that have examined age-related changes in mechanotransduction, and discuss mechanosensitive systems implicated in other tissues.
AB - Improvements in health and nutrition have increased human longevity over the past centuries. Beneficial increases in lifespan, however, are met with novel degenerative and age-related diseases, including atherosclerosis and heart disease, sarcopenia, diabetes, and osteoporosis. The effects of aging upon the skeleton include anatomically heterogeneous involution, alterations in the composition of both the organic and mineral component of the matrix, and accumulation of microdamage. It has been suggested that the process of mechanotransduction within bone is also affected by aging. Within this chapter, we review the process of mechanotransduction in osteogenic cells, highlight those works that have examined age-related changes in mechanotransduction, and discuss mechanosensitive systems implicated in other tissues.
KW - Fluid Shear Stress
KW - Nitric Oxide
KW - Osteoblastic Cell
KW - PGE2 Release
KW - Skeletal Homeostasis
UR - http://www.scopus.com/inward/record.url?scp=85085211377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085211377&partnerID=8YFLogxK
U2 - 10.1007/8415_2011_109
DO - 10.1007/8415_2011_109
M3 - Chapter
AN - SCOPUS:85085211377
T3 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
SP - 177
EP - 190
BT - Studies in Mechanobiology, Tissue Engineering and Biomaterials
PB - Springer
ER -