Bone Cell Mechanoresponsiveness

Damian C. Genetos; Christopher R. Jacobs

doi:10.1007/8415_2011_109

Bone Cell Mechanoresponsiveness

Damian C. Genetos, Christopher R. Jacobs

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Improvements in health and nutrition have increased human longevity over the past centuries. Beneficial increases in lifespan, however, are met with novel degenerative and age-related diseases, including atherosclerosis and heart disease, sarcopenia, diabetes, and osteoporosis. The effects of aging upon the skeleton include anatomically heterogeneous involution, alterations in the composition of both the organic and mineral component of the matrix, and accumulation of microdamage. It has been suggested that the process of mechanotransduction within bone is also affected by aging. Within this chapter, we review the process of mechanotransduction in osteogenic cells, highlight those works that have examined age-related changes in mechanotransduction, and discuss mechanosensitive systems implicated in other tissues.

Original language	English (US)
Title of host publication	Studies in Mechanobiology, Tissue Engineering and Biomaterials
Publisher	Springer
Pages	177-190
Number of pages	14
DOIs	https://doi.org/10.1007/8415_2011_109
State	Published - Jan 1 2013
Externally published	Yes

Publication series

Name	Studies in Mechanobiology, Tissue Engineering and Biomaterials
Volume	5
ISSN (Print)	1868-2006
ISSN (Electronic)	1868-2014

Keywords

Fluid Shear Stress
Nitric Oxide
Osteoblastic Cell
PGE2 Release
Skeletal Homeostasis

ASJC Scopus subject areas

Biomedical Engineering
Mechanics of Materials
Biomaterials
Biotechnology
Biophysics
Medicine (miscellaneous)

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