Bone Cell Mechanoresponsiveness

Damian C. Genetos, Christopher R. Jacobs

Research output: Chapter in Book/Report/Conference proceedingChapter


Improvements in health and nutrition have increased human longevity over the past centuries. Beneficial increases in lifespan, however, are met with novel degenerative and age-related diseases, including atherosclerosis and heart disease, sarcopenia, diabetes, and osteoporosis. The effects of aging upon the skeleton include anatomically heterogeneous involution, alterations in the composition of both the organic and mineral component of the matrix, and accumulation of microdamage. It has been suggested that the process of mechanotransduction within bone is also affected by aging. Within this chapter, we review the process of mechanotransduction in osteogenic cells, highlight those works that have examined age-related changes in mechanotransduction, and discuss mechanosensitive systems implicated in other tissues.

Original languageEnglish (US)
Title of host publicationStudies in Mechanobiology, Tissue Engineering and Biomaterials
Number of pages14
StatePublished - Jan 1 2013
Externally publishedYes

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials
ISSN (Print)1868-2006
ISSN (Electronic)1868-2014


  • Fluid Shear Stress
  • Nitric Oxide
  • Osteoblastic Cell
  • PGE2 Release
  • Skeletal Homeostasis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanics of Materials
  • Biomaterials
  • Biotechnology
  • Biophysics
  • Medicine (miscellaneous)


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