Improvements in health and nutrition have increased human longevity over the past centuries. Beneficial increases in lifespan, however, are met with novel degenerative and age-related diseases, including atherosclerosis and heart disease, sarcopenia, diabetes, and osteoporosis. The effects of aging upon the skeleton include anatomically heterogeneous involution, alterations in the composition of both the organic and mineral component of the matrix, and accumulation of microdamage. It has been suggested that the process of mechanotransduction within bone is also affected by aging. Within this chapter, we review the process of mechanotransduction in osteogenic cells, highlight those works that have examined age-related changes in mechanotransduction, and discuss mechanosensitive systems implicated in other tissues.