Bone and cartilage differentiation

Research output: Contribution to journalArticle

316 Citations (Scopus)

Abstract

Recent progress in the study of regulation of bone and cartilage differentiation has come from the isolation, cloning, and expression of genes encoding bone morphogenetic proteins (BMPs). BMPs initiate cartilage and bone formation in a sequential cascade. Their pleiotropic effects on chemotaxis, mitosis, and differentiation are based on concentration-dependent thresholds. The existence of multiple members of the BMP family raises issues concerning functional redundancy. Current work in progress in different laboratories has revealed that BMP-2 or BMP-4 gene knockout by homologous recombination results, surprisingly, in embryonic lethality. Cartilage and bone differentiation during endochondral development involves a continuum of steps: initiation, promotion, maintenance, modeling, and termination. The signaling factors for initiation and maintenance are being defined at the molecular level, and future studies will focus on the gene regulation of initial signaling molecules such as BMPs. Critical progress in the determination of the role of BMPs in bone development has been accomplished by systematic study of skeletal mutations such as short ear and brachypodism in mice. The accelerating pace of advance in this area augurs well for the resolution of the molecular basis of morphogenesis of bone and cartilage.

Original languageEnglish (US)
Pages (from-to)737-744
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume4
Issue number5
DOIs
StatePublished - 1994
Externally publishedYes

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Bone Morphogenetic Proteins
Cartilage
Bone and Bones
Maintenance
Bone Morphogenetic Protein 4
Bone Morphogenetic Protein 2
Peptide Initiation Factors
Gene Knockout Techniques
Homologous Recombination
Bone Development
Chemotaxis
Morphogenesis
Mitosis
Osteogenesis
Ear
Organism Cloning
Gene Expression
Mutation
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Bone and cartilage differentiation. / Reddi, A Hari.

In: Current Opinion in Genetics and Development, Vol. 4, No. 5, 1994, p. 737-744.

Research output: Contribution to journalArticle

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