Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD Homolog hlh-1

Lihsia Chen, Michael Krause, Bruce Draper, Harold Weintraub, Andrew Fire

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

The myoD family of DNA binding proteins has been implicated in the control of myogenesis in a variety of organisms. Searches for homologs in the nematode Caenorhabditis elegans yielded only one gene, designated hlh-1, expressed in body-wall muscle cells and their precursors. To assess the role of hlh-1 in C. elegans myogenesis, genetic deficiencies spanning the hlh-1 locus were isolated after gamma irradiation. Embryos homozygous for these deficiencies exhibited extensive body-wall muscle differentiation, including expression of several characteristic myofilament proteins and weak contracile behavior. Thus, zygotic hlh-1 expression was not required for body-wall muscle precursors to adopt muscle cell fates.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalScience
Volume256
Issue number5054
StatePublished - Apr 10 1992
Externally publishedYes

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    Chen, L., Krause, M., Draper, B., Weintraub, H., & Fire, A. (1992). Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD Homolog hlh-1. Science, 256(5054), 240-243.