Body size, physical activity, and risk of Hodgkin's lymphoma in women

Theresa H Keegan, Sally L. Glaser, Christina A. Clarke, Ronald F. Dorfman, Risa B. Mann, Joseph A. DiGiuseppe, Ellen T. Chang, Richard F. Ambinder

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Few studies have examined the associations of body size and physical activity with the development of Hodgkin's lymphoma (HL) in women. In data from a population-based case-control study in women ages 19 to 79 years, we assessed the relation of self-report height, weight, body mass index (BMI), and strenuous physical activity to HL risk in 312 cases with diagnostic re-review and 325 random-digit dialed controls using logistic regression. Analyses were stratified by age group and tumor cell presence of EBV. After adjustment for social class measures, taller childhood and adult height were associated with higher HL risk. In women ages 19 to 44 years, HL risk was elevated for higher, but healthy, BMI values, whereas in women ages 45 to 79 years, associations with BMI were inverse. The odds of developing HL were lower with participation (versus nonparticipation) in strenuous physical activity in the past year [odds ratio (OR), 0.58; 95% confidence interval (95% CI), 0.39-0.87 in women 19-44 years; OR, 0.45; 95% CI, 0.19-1.06 in women 45-79 years] and throughout adult life, and with sports team membership (versus nonmembership) in high school and/or at ages 18 to 22 years. Results were similar in cases (n = 269) with and without tumor-cell EBV compared with controls, although the inverse association with physical activity was somewhat stronger for women with EBV-positive disease. These findings show that in women, body size and strenuous physical activity, both modifiable characteristics, are associated with HL risk in adult life possibly through immunologic, infectious, or genetic mechanisms.

Original languageEnglish (US)
Pages (from-to)1095-1101
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Fingerprint

Body Size
Hodgkin Disease
Exercise
Human Herpesvirus 4
Body Mass Index
Odds Ratio
Confidence Intervals
Social Class
Self Report
Sports
Case-Control Studies
Neoplasms
Age Groups
Logistic Models
Weights and Measures
Population

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Keegan, T. H., Glaser, S. L., Clarke, C. A., Dorfman, R. F., Mann, R. B., DiGiuseppe, J. A., ... Ambinder, R. F. (2006). Body size, physical activity, and risk of Hodgkin's lymphoma in women. Cancer Epidemiology Biomarkers and Prevention, 15(6), 1095-1101. https://doi.org/10.1158/1055-9965.EPI-06-0020

Body size, physical activity, and risk of Hodgkin's lymphoma in women. / Keegan, Theresa H; Glaser, Sally L.; Clarke, Christina A.; Dorfman, Ronald F.; Mann, Risa B.; DiGiuseppe, Joseph A.; Chang, Ellen T.; Ambinder, Richard F.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 6, 06.2006, p. 1095-1101.

Research output: Contribution to journalArticle

Keegan, TH, Glaser, SL, Clarke, CA, Dorfman, RF, Mann, RB, DiGiuseppe, JA, Chang, ET & Ambinder, RF 2006, 'Body size, physical activity, and risk of Hodgkin's lymphoma in women', Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 6, pp. 1095-1101. https://doi.org/10.1158/1055-9965.EPI-06-0020
Keegan, Theresa H ; Glaser, Sally L. ; Clarke, Christina A. ; Dorfman, Ronald F. ; Mann, Risa B. ; DiGiuseppe, Joseph A. ; Chang, Ellen T. ; Ambinder, Richard F. / Body size, physical activity, and risk of Hodgkin's lymphoma in women. In: Cancer Epidemiology Biomarkers and Prevention. 2006 ; Vol. 15, No. 6. pp. 1095-1101.
@article{dd619156f74b4dfc984a8814a75f6b8a,
title = "Body size, physical activity, and risk of Hodgkin's lymphoma in women",
abstract = "Few studies have examined the associations of body size and physical activity with the development of Hodgkin's lymphoma (HL) in women. In data from a population-based case-control study in women ages 19 to 79 years, we assessed the relation of self-report height, weight, body mass index (BMI), and strenuous physical activity to HL risk in 312 cases with diagnostic re-review and 325 random-digit dialed controls using logistic regression. Analyses were stratified by age group and tumor cell presence of EBV. After adjustment for social class measures, taller childhood and adult height were associated with higher HL risk. In women ages 19 to 44 years, HL risk was elevated for higher, but healthy, BMI values, whereas in women ages 45 to 79 years, associations with BMI were inverse. The odds of developing HL were lower with participation (versus nonparticipation) in strenuous physical activity in the past year [odds ratio (OR), 0.58; 95{\%} confidence interval (95{\%} CI), 0.39-0.87 in women 19-44 years; OR, 0.45; 95{\%} CI, 0.19-1.06 in women 45-79 years] and throughout adult life, and with sports team membership (versus nonmembership) in high school and/or at ages 18 to 22 years. Results were similar in cases (n = 269) with and without tumor-cell EBV compared with controls, although the inverse association with physical activity was somewhat stronger for women with EBV-positive disease. These findings show that in women, body size and strenuous physical activity, both modifiable characteristics, are associated with HL risk in adult life possibly through immunologic, infectious, or genetic mechanisms.",
author = "Keegan, {Theresa H} and Glaser, {Sally L.} and Clarke, {Christina A.} and Dorfman, {Ronald F.} and Mann, {Risa B.} and DiGiuseppe, {Joseph A.} and Chang, {Ellen T.} and Ambinder, {Richard F.}",
year = "2006",
month = "6",
doi = "10.1158/1055-9965.EPI-06-0020",
language = "English (US)",
volume = "15",
pages = "1095--1101",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "6",

}

TY - JOUR

T1 - Body size, physical activity, and risk of Hodgkin's lymphoma in women

AU - Keegan, Theresa H

AU - Glaser, Sally L.

AU - Clarke, Christina A.

AU - Dorfman, Ronald F.

AU - Mann, Risa B.

AU - DiGiuseppe, Joseph A.

AU - Chang, Ellen T.

AU - Ambinder, Richard F.

PY - 2006/6

Y1 - 2006/6

N2 - Few studies have examined the associations of body size and physical activity with the development of Hodgkin's lymphoma (HL) in women. In data from a population-based case-control study in women ages 19 to 79 years, we assessed the relation of self-report height, weight, body mass index (BMI), and strenuous physical activity to HL risk in 312 cases with diagnostic re-review and 325 random-digit dialed controls using logistic regression. Analyses were stratified by age group and tumor cell presence of EBV. After adjustment for social class measures, taller childhood and adult height were associated with higher HL risk. In women ages 19 to 44 years, HL risk was elevated for higher, but healthy, BMI values, whereas in women ages 45 to 79 years, associations with BMI were inverse. The odds of developing HL were lower with participation (versus nonparticipation) in strenuous physical activity in the past year [odds ratio (OR), 0.58; 95% confidence interval (95% CI), 0.39-0.87 in women 19-44 years; OR, 0.45; 95% CI, 0.19-1.06 in women 45-79 years] and throughout adult life, and with sports team membership (versus nonmembership) in high school and/or at ages 18 to 22 years. Results were similar in cases (n = 269) with and without tumor-cell EBV compared with controls, although the inverse association with physical activity was somewhat stronger for women with EBV-positive disease. These findings show that in women, body size and strenuous physical activity, both modifiable characteristics, are associated with HL risk in adult life possibly through immunologic, infectious, or genetic mechanisms.

AB - Few studies have examined the associations of body size and physical activity with the development of Hodgkin's lymphoma (HL) in women. In data from a population-based case-control study in women ages 19 to 79 years, we assessed the relation of self-report height, weight, body mass index (BMI), and strenuous physical activity to HL risk in 312 cases with diagnostic re-review and 325 random-digit dialed controls using logistic regression. Analyses were stratified by age group and tumor cell presence of EBV. After adjustment for social class measures, taller childhood and adult height were associated with higher HL risk. In women ages 19 to 44 years, HL risk was elevated for higher, but healthy, BMI values, whereas in women ages 45 to 79 years, associations with BMI were inverse. The odds of developing HL were lower with participation (versus nonparticipation) in strenuous physical activity in the past year [odds ratio (OR), 0.58; 95% confidence interval (95% CI), 0.39-0.87 in women 19-44 years; OR, 0.45; 95% CI, 0.19-1.06 in women 45-79 years] and throughout adult life, and with sports team membership (versus nonmembership) in high school and/or at ages 18 to 22 years. Results were similar in cases (n = 269) with and without tumor-cell EBV compared with controls, although the inverse association with physical activity was somewhat stronger for women with EBV-positive disease. These findings show that in women, body size and strenuous physical activity, both modifiable characteristics, are associated with HL risk in adult life possibly through immunologic, infectious, or genetic mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=33745726120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745726120&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-06-0020

DO - 10.1158/1055-9965.EPI-06-0020

M3 - Article

C2 - 16775165

AN - SCOPUS:33745726120

VL - 15

SP - 1095

EP - 1101

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 6

ER -