Body size changes in relation to postmenopausal breast cancer among women on Long Island, New York

Sybil M. Eng, Marilie D. Gammon, Mary Beth Terry, Lawrence H. Kushi, Susan L. Teitelbaum, Julie A. Britton, Alfred I. Neugut

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

To examine effects of body size change on postmenopausal breast cancer, the authors conducted a population-based case-control study among 990 cases and 1,006 controls participating in the Long Island Breast Cancer Study Project in 1996-1997. Women who had gained more than 15 kg (33 pounds) since age 20 years were at a 1.6-fold increased risk of breast cancer (95% confidence interval (CI): 1.11, 2.26) relative to their counterparts with stable (±3 kg) weight. Subjects who had gained more than 11 kg (24 pounds) during the peri- and post-menopausal years (since age 50 years) had 1.62 times the risk of breast cancer of those whose weight remained unchanged during this time period. This effect of peri- and postmenopausal body size gain was present only among never users of hormone replacement therapy (odds ratio (OR) = 2.02 (95% CI: 1.35, 3.02) as opposed to 0.81 (95% CI: 0.43, 1.53) for ever users; multiplicative interaction: p < 0.01) and was more pronounced among women with estrogen receptor-positive/progesterone receptor-positive breast cancer (OR = 2.17, 95% CI: 1.38, 3.42). Weight loss over the lifetime was associated with decreased risk of postmenopausal breast cancer (OR = 0.55, 95% CI: 0.32, 0.96). These results add to the literature by focusing on the perimenopausal weight trajectory and support efforts urging women to avoid weight gain as they age.

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
JournalAmerican Journal of Epidemiology
Volume162
Issue number3
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

Body Size
Islands
Breast Neoplasms
Confidence Intervals
Odds Ratio
Weights and Measures
Hormone Replacement Therapy
Progesterone Receptors
Estrogen Receptors
Weight Gain
Case-Control Studies
Weight Loss
Population

Keywords

  • Body size
  • Body weight changes
  • Breast neoplasms
  • Menopause
  • Perimenopause
  • Postmenopause
  • Women

ASJC Scopus subject areas

  • Epidemiology

Cite this

Eng, S. M., Gammon, M. D., Terry, M. B., Kushi, L. H., Teitelbaum, S. L., Britton, J. A., & Neugut, A. I. (2005). Body size changes in relation to postmenopausal breast cancer among women on Long Island, New York. American Journal of Epidemiology, 162(3), 229-237. https://doi.org/10.1093/aje/kwi195

Body size changes in relation to postmenopausal breast cancer among women on Long Island, New York. / Eng, Sybil M.; Gammon, Marilie D.; Terry, Mary Beth; Kushi, Lawrence H.; Teitelbaum, Susan L.; Britton, Julie A.; Neugut, Alfred I.

In: American Journal of Epidemiology, Vol. 162, No. 3, 08.2005, p. 229-237.

Research output: Contribution to journalArticle

Eng, SM, Gammon, MD, Terry, MB, Kushi, LH, Teitelbaum, SL, Britton, JA & Neugut, AI 2005, 'Body size changes in relation to postmenopausal breast cancer among women on Long Island, New York', American Journal of Epidemiology, vol. 162, no. 3, pp. 229-237. https://doi.org/10.1093/aje/kwi195
Eng, Sybil M. ; Gammon, Marilie D. ; Terry, Mary Beth ; Kushi, Lawrence H. ; Teitelbaum, Susan L. ; Britton, Julie A. ; Neugut, Alfred I. / Body size changes in relation to postmenopausal breast cancer among women on Long Island, New York. In: American Journal of Epidemiology. 2005 ; Vol. 162, No. 3. pp. 229-237.
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