Body Region Involvement and Quality of Life in Psoriasis: Analysis of a Randomized Controlled Trial of Adalimumab

April W. Armstrong, Delfina Guadalupe Villanueva Quintero, Cristina M. Echeverría, Yihua Gu, Mahinda Karunaratne, Ofelia Reyes Servín

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Psoriasis severity and treatment responsiveness vary by body region, which differentially impacts quality of life (QoL). Objective: The objective of the study was to examine adalimumab efficacy by body region and regional response and QoL relationship. Methods: Patients (n = 1212) with moderate-to-severe psoriasis were randomized 2:1 to 80 mg at week 0, followed by adalimumab 40 mg or placebo every other week for 16 weeks in the double-blind REVEAL study. Psoriasis Area and Severity Index (PASI) responses and Dermatology Life Quality Index outcomes were analyzed. Results: Week 16 regional mean PASI improvements were significantly greater with adalimumab (83.1 ± 1.57, 81.3 ± 1.58, 75.7 ± 1.34, and 73.9 ± 1.26% in the trunk, head, upper extremities, and lower extremities, respectively; all p < 0.001 vs. placebo). Likewise, percentages of patients with regional PASI ≥75/≥90/100% reduction from baseline were significantly higher with adalimumab (all p < 0.001); adalimumab responses were greater for the trunk (77.9/65.0/59.1%) and head (74.6/66.1/62.8%; all p ≤ 0.0001 vs. lower) than upper (67.7/45.1/39.6%; p = 0.4, p = 0.04, p = 0.0005, respectively, vs. lower) and lower extremities (65.7/40.0/31.3%). Adalimumab significantly improved Dermatology Life Quality Index scores vs. placebo (8.2- vs 1.7-point decrease from baseline; p < 0.001). Limitations: The study was a post hoc analysis. Conclusions: Adalimumab treatment resulted in statistically significant and clinically meaningful improvements in disease severity and QoL. QoL improvements were associated with PASI responses in all body regions. Trial Registration: ClinicalTrials.gov identifier NCT00237887.

Original languageEnglish (US)
Pages (from-to)691-699
Number of pages9
JournalAmerican Journal of Clinical Dermatology
Volume17
Issue number6
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Dermatology

Cite this

Armstrong, A. W., Villanueva Quintero, D. G., Echeverría, C. M., Gu, Y., Karunaratne, M., & Reyes Servín, O. (2016). Body Region Involvement and Quality of Life in Psoriasis: Analysis of a Randomized Controlled Trial of Adalimumab. American Journal of Clinical Dermatology, 17(6), 691-699. https://doi.org/10.1007/s40257-016-0229-x